Aim: The objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic profile, compatibility with other formulation excipients physico-chemical parameters new drug substance. This could provide important information for design or support need molecular modification. So, in present studies were performed on Glimepiride (GMP) assess i...

As the final outcome of our work in the context of the Wisdom project, a prototype for query formulation has been developed in order to prove the validity of the M-FIRE framework [3, 5, 4], and the feasibility of our approach to knowledge representation and exploration. The prototype includes a client module (written in C#) and a server module (written in Java) which communicate through a state...

Robust AI systems need to be able to reason about their goals and formulate new goals based on the given situation. Case-based goal formulation is a technique for formulating new goals for an agent using a library of examples. We provide a formalization of this term and two algorithms that implement this definition. The algorithms are compared against classification techniques on the tasks of o...

During the last decade, there has been a growing interest in developing nonlinear model-based control methods. This interest has led to substantial progress mainly within the two frameworks of model predictive control (MPC) and differential geometric control. MPC is an optimization-based control methodology which explicitly accounts for process constraints and in general leads to a controller w...

www.pharmtech.com yophilization or freeze-drying is often used to stabilize various pharmaceutical products, including virus vaccines, protein and peptide formulations, liposome, and small-chemical drug formulations (1–4). Often a pharmaceutical product may be susceptible to physical and chemical degradation when stored as a ready-to-use solution. The goal of the formulations scientist is to id...