The purpose of this study is to propose the flotation procedure seafloor massive sulfide (SMS) ores separate chalcopyrite and galena as froth sphalerite, pyrite, other gangue minerals tailings, which currently facing difficulties due presence water-soluble compounds. obtained SMS ore sample contains CuFeS2, ZnS, FeS2, SiO2, BaSO4 in addition PbS PbSO4 Pb minerals. Soluble compounds releasing Pb...