نتایج جستجو برای: fshr and estrogenic enzymes 17βhsd
تعداد نتایج: 16837623 فیلتر نتایج به سال:
Background: According to CDC, polycystic ovarian syndrome (PCOS) is responsible for infertility in women with 6-12% incidences all over the world. The current treatment options available have several side effects such as amenorrhea and obesity amongst others. Dietary interventions non-estrogenic androgen-suppressing foods along nutraceutical products considered treating PCOS minimum effects. On...
Indole-3-carbinol (I3C), found in cruciferous vegetables, has been shown to suppress or promote carcinogenesis depending on various animal models. Regarding its preventive effects, I3C acts as an anti-estrogen and can induce apoptosis, but precise mechanisms remain to be determined. Since I3C induces cytochrome P450 enzymes in the liver, it affects hydroxylation of estrogens and might therefore...
Combined Effects of the FSHR 2039 A/G and FSHR -29 G/A Polymorphisms on Male Reproductive Parameters
Background Polycystic ovary syndrome (PCOS) is often associated with higher levels of LH, and arrested ovarian follicular growth. The direct impact high LH on FSH mediated metabolic responses in PCOS patients not clearly understood. Method In order to investigate the glucose metabolism preovulatory granulosa cells (GCs), we used [U14C]-2 deoxyglucose, D-[U14C]-glucose or 2-NBD analyse uptake it...
The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...
Introduction . Normal ovarian reserve (OR) determining the response to follicle development containing fully-featured oocytes is an important factor in pregnancy, including assisted reproductive technology (ART) programs. The causes of premature OR decrease are multifactorial. study gene polymorphism as a cause deserves attention. Aim : determine genetic predisposition and create prognostic mod...
به ناتوانی زوجین جهت باروری علی رغم داشتن رابطه جنسی مطلوب بعد از مدت زمان یک سال ناباروری اطلاق می گردد. تقریبا 12% از جمعیت جهان نابارورند. یکی از مهمترین دلایل ناباروری جهش در ژن هایی است که در محور هیپوتالاموس- هیپوفیز-گناد (hpg) بیان می شوند. ژن گیرنده هورمون محرک فولیکولی ((fshr توسط سلول های گرانولوزا در تخمدان بیان می شود و نقش مهمی در باروری زنان مانند تکثیر سلول های گرانولوزا، تنظیم م...
The cause of polycystic ovary syndrome (PCOS), a complex endocrine disorder, is unknown, but its familial aggregation implies underlying genetic influences. Hyperandrogenemia is regarded as a major endocrine character of the PCOS. In this study, we employed bisulfite sequencing and bisulfite restriction analysis to investigate the DNA methylation status of LHR, AR, FSHR and H19 in dehydroepiand...
STUDY QUESTION Does the sperm DNA fragmentation index (DFI) improve depending on the FSH receptor (FSHR) genotype as assessed by the nonsynonymous polymorphisms rs6166 (p.N680S) after 3 months of recombinant FSH treatment in men with idiopathic infertility? SUMMARY ANSWER FSH treatment significantly improves sperm DFI only in idiopathic infertile men with the p.N680S homozygous N FSHR. WHAT...
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