In the title compound, C(13)H(13)FN(2)O(3), the fused piperidine ring is in a chair conformation. The fused pyrrolidine ring shows an envelope conformation with the N atom displaced by 0.661 (3) Å out of the plane formed by the four C atoms of the pyrrolidine ring. The dihedral angle between this plane and the plane formed by the four attached C atoms of the piperidine ring (not including the c...

We developed an asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2-carboxylates using 10 mol% of a chiral phosphoric acid. The products, which are novel bisindole-piperidine-amino acid hybrids, can be obtained in one step from 3-vinyl indoles with imino esters in dichloromethane at room temperature after 1 h of reaction time. A variety of these compounds could be synth...

In the title piperidine derivative, C21H22Cl2N2O, the piperidine ring adopts a chair conformation. The chloro-phenyl rings are oriented at an angle of 45.59 (14)° with respect to each other. In the crystal, mol-ecules are linked via N-H⋯O hydrogen bonds, forming C(4) chains along [100]. The chains are linked by C-H⋯O hydrogen bonds, forming sheets parallel to the ab plane. Within the sheets, th...

In title compound, [PtCl2(C15H21N3O2)2], the Pt(II) cation, located on an inversion center, is coordinated by two Cl(-) anions and two 3-(4-meth-oxy-phen-yl)-2-methyl-5-(piperidin-1-yl)-2,3-di-hydro-1,2,4-oxa-diazole ligands in a distorted Cl2N2 square-planar geometry. The di-hydro-oxa-diazole and piperidine rings display envelope (with the non-coordinating N atom as the flap atom) and chair co...

In the title mol-ecular salt, C12H22N5(+)·Cl(-), the cation is protonated at the dimethyl-substituted tertiary N atom. The piperidine ring adopts a chair conformation with the exocyclic N-C bond in an equatorial orientation. The dihedral angle between the piperidine ring (all atoms) and the pyrimidine ring is 14.00 (1)°. In the crystal, the ions are connected by N-H⋯N hydrogen bonds, forming in...

The title compound, C13H17NO3, adopts a conformation in which the aromatic ring and the mean plane of the piperidine ring are almost perpendicular to each other [dihedral angle = 79.25 (6)°]. The presence of the carbonyl group alters the conformation of the piperidine ring from a chair to a twisted half-chair conformation. In the crystal, pairs of strong O-H⋯O hydrogen bonds link the mol-ecules...

In the title mol-ecule, C(23)H(21)NO, the piperidine ring adopts a chair conformation, with the N and carbonyl C atoms as flaps, which deviate on either side of the chair by -0.706 (3) and 0.494 (3) Å, respectively. All three phenyl rings are in equatorial positions on the piperidine ring, making angles with the puckering plane of 73.5 (1), 73.1 (1) and 67.2 (1)°. Though there is no classical h...

In the title compound, C(20)H(19)N O(2)S(2),the 3Hbenzo-chromene ring system is nearly planar, with a maximum deviation of 0.036 (2) Å, and the piperidine ring adopts a chair conformation: the bond-angle sum for its N atom is 358.7°. The dihedral angle between the 3H-benzo[f]chromene ring and the piperidine ring is 89.07 (8)°. In the crystal, C-H⋯O hydrogen bonds lead to [010] C(6) chains and w...

In the title mol-ecule, C(20)H(20)Cl(2)N(2)O(2), the piperidine ring adopts a chair conformation and the nitroso group at position 1 has a bis-ectional orientation. The two benzene rings and the isopropyl group attached to the piperidine ring in positions 2, 6 and 3, respectively, have axial orientations. The dihedral angle between the two benzene rings is 21.56 (13)°. One of the Cl atoms is di...

Minoxidil is a piperidine-pyrimidine derivative and potent vasodilator approved orally for severe hypertension topically androgenetic alopecia (AGA).[1][1] The minimum plasma threshold induction of hair growth an order magnitude below the required any hemodynamic