نتایج جستجو برای: fungal drug resistance
تعداد نتایج: 954025 فیلتر نتایج به سال:
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an encapsulated fungal pathogen that can cause fungal pneumonia and life-threatening infections of the central nervous system (CNS) [1]. C. neoformans can be found ubiquitously throughout the environment [1]. Inhalation of airborne yeast or desiccated basidiospores typically results in asymptomatic disease or dorma...
سرطان نوعی بیماری است که در آن سلول ها توانایی تقسیم و رشد عادی خود را از دست می دهند ازاجتماع این سلول های سرطانی, توده ای به نام تومور ایجاد می شود. مرگ ناشی از سرطان در سال ???? ، ?/? میلیون نفر بوده است که ??%از کل ?? میلیون مرگ در سراسرجهان رابه خوداختصاص میدهد. سرطان کلورکتال که به نام های سرطان کلون یا روده نیز خوانده می شود، در پی رشد سلول های سرطانی در کولون، رکتوم و آپاندیس بروز می...
conclusion prevalence of p. aeruginosa producing esbl and mdr strains from our clinical samples and environment is still low. results the highest resistance rates from the isolated p. aeruginosa were shown against piperacillin, imipenem, cefotaxime, ceftriaxone, gentamicin, ceftazidime, aztreonam, and ciprofloxacin, respectively. seven isolates (9.2%) were esbl producers. more than 30% of the i...
Multi-drug resistance of pathogenic microorganisms is becoming a serious threat, particularly to immunocompromised populations. The high mortality of systematic fungal infections necessitates novel antifungal drugs and therapies. Unfortunately, with traditional drug discovery approaches, only echinocandins was approved by FDA as a new class of antifungals in the past two decades. Drug efflux is...
5-Flucytosine is currently used as an antifungal drug in combination therapy, but fungal pathogens are rapidly able to develop resistance against this drug, compromising its therapeutic action. The understanding of the underlying resistance mechanisms is crucial to deal with this problem. In this work, the S. cerevisiae deletion mutant collection was screened for increased resistance to flucyto...
The evolution of resistance to drugs is a major public health concern as it erodes the efficacy of our therapeutic arsenal against bacterial, viral, and fungal pathogens. Increasingly, it is recognized that the evolution of resistance involves genetic changes at more than one locus, both in cases where multiple changes are required to obtain high-level resistance, and where compensatory changes...
Cryptococcus neoformans is an opportunistic human pathogenic fungus that causes meningoencephalitis. Due to the increasing global risk of cryptococcosis and the emergence of drug-resistant strains, the development of predictive genetics platforms for the rapid identification of novel genes governing pathogenicity and drug resistance of C. neoformans is imperative. The analysis of functional gen...
Background : The incidence of invasive fungal infections has been increasing for two decades. Amatter of concern in the treatment of fungal infections is the limited number of efficacious antifungal drugs. Many available drugs lead to the development of resistance, In order to seek new antifungal agents we assessed the antifungal activity of newly synthesized Imidazol compounds by a coloromet...
OBJECTIVES The fungal pathogen Candida albicans forms biofilms on implanted medical devices, resulting in infections with high mortality. Fully developed biofilms, which are adherent communities of microorganisms, characteristically exhibit high resistance to antimicrobial drugs, making treatment of device-associated infection problematic. The aim of this study was to determine the effect of th...
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