Fifteen patients with acute myocardial infarction and an elevated pulmonary capillary wedge pressure were given 40 mg furosemide intravenously within 24 hr of diagnosis of infarction. We divided the patients into two groups on the basis of the diuretic response to furosemide: nine who responded with a diuresis of greater than 400 ml in two hours, and six with a lower diuresis. The nine patients...

The response of patients with tinnitus to the suppressive effects of IV furosemide is about 50%. Since furosemide is a drug without known effects on the central nervous system but with well documented effects in the auditory periphery, we hypothesized that it suppressed tinnitus of peripheral origin and that the response rate was due to that selectivity. To test this hypothesis we recruited 14 ...

A sensitive, selective and efficient reversed-phase high-performance liquid chromatographic (HPLC) method is reported for the determination of furosemide in human plasma and urine. The method has a sensitivity limit of 5 ng/ml in plasma, with acceptable within- and between-day reproducibilities and good linearity (r2>0.99) over a concentration range from 0.05 to 2.00 microg/ml. The one-step ext...

While previous studies have shown that prostaglandins (PG) mediate the renal vasodilating and renin-releasing actions of furosemide, the dose-response relationship has not been defined nor has the specific PG involved. Prostacyclin (PGIj) is synthesized in the renal cortex, is a vasodilator, can release renin and, therefore, could mediate these actions of furosemide. The authors measured urinar...

While previous studies have shown that prostaglandins (PG) mediate the renal vasodilating and renin-releasing actions of furosemide, the dose-response relationship has not been defined nor has the specific PG involved. Prostacyclin (PGIj) is synthesized in the renal cortex, is a vasodilator, can release renin and, therefore, could mediate these actions of furosemide. The authors measured urinar...

The use of intravenous (IV) furosemide is common practice in patients under mechanical ventilation (MV), but its effects on respiratory mucus are largely unknown. Furosemide can affect respiratory mucus either directly through inhibition of the NaK(Cl)2 co-transporter on the basolateral surface of airway epithelium or indirectly through increased diuresis and dehydration. We investigated the ph...

As the effectiveness of beta-agonists for treating asthma attacks has been established, numerous other supportive treatments for asthma attacks have also been investigated, such as systemic glucocorticoids and magnesium. Among these additional therapies, inhaled furosemide is of particular interest; several studies have evaluated the effects of prophylactic inhaled furosemide in attenuating bro...

Chronic infusion of loop diuretics into animals induces structural and functional changes in the distal nephron. These changes include increases in the activity of the thiazide-sensitive Na(+)/Cl(-)-cotransporter (NCC). The NCC was recently demonstrated to be an aldosterone-induced protein. These experiments were designed to test the hypotheses that chronic loop diuretic infusion, with replacem...

Acute kidney injury (AKI) is associated with high mortality resulting from extra-renal organ damage, particularly the heart. The present study aimed to investigate the protective effect of sitagliptin, a dipeptidyl peptidase-4 (DPP4) inhibitor, against renal and remote cardiac damage induced by ischemia/reperfusion (IR), a leading cause of AKI. In this attempt, we compared the effects of sitagl...

The antihypertensive properties of single doses of furosemide were evaluated in 113 patients. Doses over 120 mg consistently produced a fall in arterial pressure whereas smaller doses did not. Thus 20 of 22 patients (90%) who received more than 120 mg had a 26 + 6% average reduction in mean arterial pressure. The hypotensive action began in 30 to 45 minutes, the nadir of the decrease occurred b...