ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. twenty–four male wistar rats (250-300 g body wt) were used in this study. the animals were divided into four groups of 6 rat...

an efficient synthesis of polyhydroquinoline derivatives is achieved via hantzsch condensation reaction between aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of catalytic amount of sfhs in ethanol. this method gives remarkable advantages such as shorter reaction time, simple workup procedure and good to excellent yields. furthermore the catalyst can be recovered c...

in this article, we develop the distributed order fractional hybrid differential equations (dofhdes) with linear perturbations involving the fractional riemann-liouville derivative of order $0 < q < 1$ with respect to a nonnegative density function. furthermore, an existence theorem for the fractional hybrid differential equations of distributed order is proved under the mixed $varphi$-lipschit...

a large collection of botryosphaeriaceae isolates obtained from fruit and forest trees with fruit rot, canker and dieback disease symptoms in northern provinces of the country were examined in this study. based on morphology and sequence data (its and ef1-α), two species, diplodia mutila and spencermartinsia viticola are illustrated and described as new records for iran mycobiota. furthermore, ...

background: breast cancer (bc) is the second most commonly diagnosed cancer after lung cancer. survival of bc patients is affected by intermediate events. this study was aimed to investigate the disease course of primary non-metastatic bc patients with first recurrence of the tumor (frt) as the intermediate event using the illness- death model. methods: this retrospective cohort study was condu...

objective(s):previous studies demonstrate that changes in pre-mrna splicing play a significant role in human disease development. furthermore, many cancer-associated genes are regulated by alternative splicing. there are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. located on the x chromosome, ...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

background: multiple sclerosis is a common and chronic neurologic disorder. this disorder imposes physical, economic, and psychosocial burden on individuals, their families and society. this study aims to analyze the costs of multiple sclerosis disease based on the severity of disability. methods: we performed a cross‑sectional cost of illness study. this study was conducted in 332 patients of ...

introduction: cochlear implantation (ci) improves language skills among children with hearing loss. however, children with cis still fall short of fulfilling some other needs, including musical perception. this is often attributed to the biological, technological, and acoustic limitations of cis. emotions play a key role in the understanding and enjoyment of music. the present study aimed to in...

introduction: the family of each hearing-impaired child has its own cultural, social, educational, and financial background, and its own special needs. the objectives of our study were to explore the information and support needs of parents of children with severe-to-profound hearing impairment and to investigate the effects of the parents’ level of education and economic status on the score at...