This paper presents a framework to support analysis and trend detection in historical data from Neonatal Intensive Care Unit (NICU) patients. The clinical research extensions contribute to fundamental data mining framework research through the integration of temporal abstraction and support of null hypothesis testing within the data mining processes. The application of this new data mining appr...

Cancer cells rapidly evolve a multitude of defense mechanisms to evade the effects of the oncologist's drug arsenal. Unfortunately, clinical strategies to overcome these lag far behind. This mismatch likely underlies our inability to implement new durable treatment strategies. Here, a new form of multidrug resistance, inducible drug glucuronidation, is discussed. This form was discovered while ...

Perhaps the academic disclaimer ‘at time of writing’ has never been so unavoidable, and at same futile, as in era Trump. Since 45th president United States took of...

We describe the identification and characterization of novel homing endonucleases using genome database mining to identify putative target sites, followed by high throughput activity screening in a bacterial selection system. We characterized the substrate specificity and kinetics of these endonucleases by monitoring DNA cleavage events with deep sequencing. The endonuclease specificities revea...

OBJECTIVE To investigate how doctors define and use the terms "futility" and "futile treatment" in end-of-life care. DESIGN, SETTING, PARTICIPANTS A qualitative study using semi-structured interviews with 96 doctors from a range of specialties which treat adults at the end of life. Doctors were recruited from three large Brisbane teaching hospitals and were interviewed between May and July 20...

OBJECTIVE The aim of the study was to determine the prognosis in patients who needed norepinephrine treatment in our institution in relation to the degree of organ failure and the evolution of the disease process. DESIGN Retrospective case note analysis of outcome of those patients who needed norepinephrine according to our institutional regimen. PATIENTS A total of 100 consecutive patients...

Recanalization is strongly associated with improved functional outcomes and reduced mortality in patients with acute stroke, but reopening of large arteries may not achieve effective tissue reperfusion, may occur too late, or even may exacerbate tissue injury by reperfusion phenomenon. The so-called futile recanalization concept refers to those patients who present poor clinical outcomes despit...

BACKGROUND Empirical surveys about medical futility are scarce relative to its theoretical assumptions. We aimed to evaluate the difference of attitudes between laypeople and physicians towards the issue. METHODS A questionnaire survey was designed. Japanese laypeople (via Internet) and physicians with various specialties (via paper-and-pencil questionnaire) were asked about whether they woul...