The problem of determining Ramsey numbers is known to be very difficult. The few known exact values and several bounds for different G1, G2 or m, n are scattered among many technical papers (see [3]). A graph G with order p is called a (G1,G2; p)-graph ((m, n; p)-graph, resp.) if G does not contain a G1 and Ḡ does not contain a G2 (Km and Kn , resp.). It is easy to see that R(G1,G2) = p0 +1 iff...

Two graphs G1 and G2 of order n pack if there exist injective mappings of their vertex sets into [n], such that the images of the edge sets are disjoint. In 1978, Bollobás and Eldridge, and independently Catlin, conjectured that if (∆(G1)+1)(∆(G2)+1)≤ n+1, then G1 and G2 pack. Towards this conjecture, we show that for ∆(G1),∆(G2)≥ 300, if (∆(G1)+1)(∆(G2)+1)≤0.6n+1, then G1 and G2 pack. This is ...

We describe a rapid PCR method that directly inserts an epitope tag into an open reading frame (ORF) to facilitate protein detection. This project was performed within a varicella-zoster virus (VZV) system. In earlier work, we produced a monoclonal antibody (MAb 3B3) to one VZV ORF called gE. MAb 3B3 bound to its epitope under extreme denaturing conditions. To further characterize the epitope, ...

Let G0 and G1 be two graphs with the same vertices. The new graph G(G0, G1;M) is a graph with the vertex set V (G0)∪V (G1) and the edge set E(G0)∪E(G1)∪M , where M is an arbitrary perfect matching between the vertices of G0 and G1, i.e., a set of cross edges with one endvertex in G0 and the other endvertex in G1. In this paper, we will show that if G0 and G1 are f -fault q-panconnected, then fo...

The role of CTL tolerance in tumor immunity to SV40 large T antigen (T ag)-induced tumors was studied using T ag transgenic mice of the line 501 (H2b). 501 mice express SV40 T ag under the influence of the alpha-amylase promoter, which leads to the development of osteogenic osteosarcomas late in life and eventual death between 12 and 17 months of age. We determined the ability of 501 mice to re...

The role of CTL tolerance in tumor immunity to SV40 large T antigen (T ag)-induced tumors was studied using T ag transgenic mice of the line 501 (H2). 501 mice express SV40 T ag under the influence of the a-amylase promoter, which leads to the development of osteogenic osteosarcomas late in life and eventual death between 12 and 17 months of age. We determined the ability of 501 mice to respond...

Abstract Platelet transfusion refractoriness results in adverse outcomes and increased health care costs. Managing resulting from HLA alloimmunization necessitates the use of antigen–matched platelets but requires a large platelet donor pool does not guarantee full matching. We report first randomized, double-blind, noninferiority, crossover trial comparing epitope–matched (HEM) with standard (...

Characterization of B-cell protein epitope and developing critical parameters for its identification is one of the long standing interests. Using Layers algorithm, we introduced the concept of anchor residues to identify epitope. We have shown that majority of the epitope is composed of anchor residues and have significant bias in epitope for these residues. We optimized the search space reduct...