BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency has been associated with acute psychosis, catatonic schizophrenia, and bipolar disorders by previous inconclusive reports. A particularly disproportionate rate of enzyme deficiency was found in manic schizoaffective patients from 662 lithium patients surveyed in Sardinia. The purpose of this study was to describe clinical character...

glucose-6-phosphate dehydrogenase (g6pd) in humans is in x-linked disorder, housekeeping enzyme and vital for the survival of every cell. it catalyses the oxidation of glucose-6-phosphate to 6-phospho gluconat in the first committed step of the pentose phosphate pathway, which provides cells with pentoses and reducing power in the form of nadph. nadph is required to protect the cells against ox...

The evolutionary conservation of a housekeeping gene such as G6PD is greater than that of tissue-specific genes, presumably because the latter may require more specific adaptation to the physiology of individual organisms. The abundance of distinct mutation sites and their clinical manifestations make G6PD ideal for structure-function analysis. Therefore, it is of interest to screen of G6PD def...

platelet adherence surrounding leucocytes in a rosette formation or platelet satellitism is a rare phenomenon. this finding has been observed almost exclusively in ethylenediaminetetraacetic acid treated blood at room temperature. the mechanism underlying this phenomenon is not fully understood. in many reports of platelet satellitism platelets clump to polymorphonuclear neutrophils in healthy ...

is known about the safety of RBV treatment in patients with concomitant glucose-6-phosphate dehydrogenase (G6PD) deficiency, who are inherently prone to hemolysis.5 We prospectively studied changes in hemoglobin (Hb) levels in 112 patients with chronic hepatitis C, associated or not with G6PD deficiency, during and after combination therapy. G6PD activity was tested by a spectrophotometric meth...

Dear Editor, I read with interest a paper from Zekavat and associates, concerning the possible association between glucose-6-phosphate dehydrogenase (G6PD) deficiency and development of preeclampsia. This study did not confirm their hypothesis that there was a relationship between G6PD and preeclampsia development. However, there is a possibility that future studies, performed using higher numb...

Glucose-6-phosphate dehydrogenase (G6PD) in humans is an X-chromosome-linked disorder and housekeeping enzyme, vital for the survival of every cell. It catalyses the oxidation of glucose-6-phosphate to 6-phospho gluconate in the first committed step of the pentose phosphate pathway, which provides cells with pentoses and reducing power in the form of NADPH. NADPH is required to protect the cell...

Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and the redox balance. G6PD deficiency is a major cause of neonatal jaundice and acute hemolyticanemia, and recently, G6PD has been associated with diseases including inflammation and cancer. The aim of the present study was to conduct a search of the...

Jaundice is a common disorder in neonates and one of the provable causes of glucose-6-phosphate dehydrogenase (G6PD) deficiency, some mutation types of which may be associated with severe neonatal icter. The present study has been conducted to compare G6PD mutations in incteric and non icteric neonates. This case-control study was implemented in the NICU and Newborn Ward of Amirkola Children Ho...

BACKGROUND The most common form of malaria outside Africa, Plasmodium vivax, is more difficult to control than P. falciparum because of the latent liver hypnozoite stage, which causes multiple relapses and provides an infectious reservoir. The African (A-) G6PD (glucose-6-phosphate dehydrogenase) deficiency confers partial protection against severe P. falciparum. Recent evidence suggests that t...