AIM To determine incidence and clinical biomarkers of marked necroinflammation and fibrosis characteristics among chronic hepatitis B (CHB) patients with persistently normal alanine aminotransferase (PNALT). METHODS Liver biopsy was performed on 115 CHB patients with PNALT. Necroinflammation and fibrosis were graded by the Knodell histologic activity index and the Ishak fibrosis score, respec...

Costs can hamper the evaluation of the effectiveness of new biomarkers. Analysis of smaller numbers of pooled specimens has been shown to be a useful cost-cutting technique. The Youden index (J), a function of sensitivity (q) and specificity (p), is a commonly used measure of overall diagnostic effectiveness. More importantly, J is the maximum vertical distance or difference between the ROC cur...

Introduction. Intertrochanteric fractures are located in the proximal upper part of the femur, extracapsulary and extend up to 5 cm under the minor trochanter (3). Intramedullary fixation is used almost exclusively for this kind of fractures in our department for many years. The most common mechanical complication of intramedullary fixation is the cut out of the sliding screw trough the femoral...

The effects of tetracaine on charge movements and on antipyrylazo III signals monitoring intracellular delta [Ca2+] were compared in cut frog semitendinosus muscle fibers in a single vaseline gap-voltage clamp. Low tetracaine concentrations (25-40 microM) markedly reduced delta [Ca2+] signals and shifted the rheobase. However, they neither influenced charge movement nor that peak delta [Ca2+] v...

background : homicide is killing of a human being by another human being. various methods like strangulation, cut throat, stabbing etc may be used for homicide; however combination of two mechanisms is rare. case report: hereby we present a rare case with unexpected appearance of two different mechanisms of homicide applied over same region, wherein body of a female was referred to us with hist...

BACKGROUND Fixation of trochanteric hip fractures using the Gamma Nail has been performed since 1988 and is today well established and wide-spread. However, a number of reports have raised serious concerns about the implant's complication rate. The main focus has been the increased risk of a subsequent femoral shaft fracture and some authors have argued against its use despite other obvious adv...

We have developed enhanced immunohistochemical protocols for detecting autonomic nerve fibers and splenocyte-associated proteins in rat spleen. This includes norepinephrine-synthesizing enzymes (dopamine-beta hydroxylase (DBH) and tyrosine hydroxylase (TH)), neuropeptide Y (NPY), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), c-fos protein, inducible nitric oxide synthas...

Context. Radio, X-ray, and gamma-ray observations provide us with strong evidence of particle acceleration to multi-TeV energies in various astrophysical sources. Diffusive shock acceleration is one of the most successful models explaining the presence of such high-energy particles. Aims. We discuss the impact of inverse Compton losses on the shock acceleration of electrons that takes place in ...

Abstract Medical surveillance for alcohol abuse and dependency at work is mandatory a list of high-risk occupations. The occupational physician the only figure entitled to perform laboratory tests on employees. This study aims investigate alcohol-induced injuries in healthcare workers, by using Carbohydrate-Deficient Transferrin (CDT) as marker during medical visits. A retrospective was carried...