PURPOSE The mechanisms that trigger ganglion cell death in ischemic retinal diseases are not clearly understood. Using a mouse optic nerve ligation model, the objective of this study was to test the hypothesis that extracellular matrix (ECM) modulating plasminogen activators (PAs) potentiate ganglion cell loss. METHODS Optic nerve ligation was performed to initiate ganglion cell loss in the r...

A chloride-free environment produces selective changes in the retinal network which include a separation of on and off channels. The identification of chloride-sensitive and insensitivie neuronal activity permits identification of some of the connections and intervening polarities of synaptic interactions which are expressed in ganglion cell receptive field organization. These experiments suppo...

THE ABDOMINAL GANGLION of the marine gastropod, ApZysia, is a valuable preparation for cellular electrophysiological studies. In large animals, most small nerve cells in this ganglion are comparable in size to the largest neurons in the vertebrate brain ganglion occasionally reach 1 (So-100 p), whereas the largest cells in the mm in diameter. Furthermore, the majority of the cells are located n...

A rule of retinal wiring is that many receptors converge onto fewer bipolar cells and still fewer ganglion cells. However, for each S cone in macaque fovea, there are two S-cone ON bipolar cells and two blue-yellow (BY) ganglion cells. To understand this apparent rule reversal, we reconstructed synaptic patterns of divergence and convergence and determined the basic three-tiered unit of connect...

Five monoclonal antibodies were selected by immunizing mice with embryonic chick optic nerve and screening the resultant hybridoma antibodies by immunofluorescence on sections of the retina. The optic nerve was chosen as the immunizing tissue since it is presumably enriched in ganglion cell-specific antigens. These antibodies bind to antigens which are largely localized to the inner part of the...

ganglion cysts commonly occur around the shoulder, mostly in the spinoglenoid and suprascapular notches. we report a very rare case of intra articular ganglion cyst of the long head of the biceps tendon that originated from the bicipital groove as a rare cause of shoulder pain.