The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was evalu...

BACKGROUND AND AIM Free radicals are implicated in the aetiology of gastrointestinal disorders such as gastric ulcer, colorectal cancer and inflammatory bowel disease. Strawberries are common and important fruit due to their high content of essential nutrient and beneficial phytochemicals which seem to have relevant biological activity on human health. In the present study we investigated the a...

Gastric digestion of protein is dependent on the hydrogen ion concentration of the stomach contents. Human gastric juice will digest casein optimally in the pH ranges 1 * 8 to 2 2 and 3 * 5 to 3 * 6. Between and above these ranges hydrolytic activity rapidly declines and is minimal between pH 2-5 and 3*2 (Taylor, 1959). Pepsin is the main enzyme concerned, but others, i.e. parapepsins, have bee...

Gastric intubation via the nasal passage is a common procedure that provides access to the stomach. A nasogastric tube (NGT) is used for diagnostic and therapeutic indications, which include evaluation of upper gastrointestinal bleeding, aspiration of gastric fluid content, gastric decompression including maintenance of a decompressed state after endotracheal intubation, relief of symptoms and ...

Noise is considered as one of the most severe sources of environmental and work place constraints. Noise effects on immune function, hormonal levels, cardiovascular and respiratory systems are well known. The aim of the study is to evaluate the effects of traffic noise on basal and stimulated gastric acid secretion. 48 healthy rats were divided into five traffic noise exposures (1, 7, 14, 21, 2...

The action of intravenous atropine on meal-and pentagastrin-induced gastric acid secretion was studied in six duodenal ulcer patients.A test meal of 10% peptone solution adjusted to pH 5.0 was maintained in the stomach at at distention presure of 15 cm H(2)O, and a modification of the intragastric titration method of Fordtran and Walsh was used to measure gastric acid output by monitoring the r...

It has been demonstrated that with few exceptions the potassium content of malignant neoplasms is increased, whereas the calcium content is decreased, relative to nonmalignant mature tissues (3). An elevated K/Ca ratio has been regarded as characteristic of malignant neoplasms. In 1932 Epstein (2) observed that the potassium content in a variety of human neoplasms was higher than that in the ti...

The effects of selective inhibitors of phosphodiesterase type IV (PDE4) on ischemia-reperfusion-induced gastric injuries were investigated in rats. Gastric ischemia was induced by applying a small clamp to the celiac artery, and reoxygenation was performed by removal of the clamp. Ischemia-reperfusion produced gastric hemorrhagic injuries and increased the content of the proinflammatory cytokin...

Gastric mucosal perfusion is increased in portal-hypertensive gastropathy, and this may contribute to gastric bleeding from these lesions. Therefore drugs reducing gastric mucosal perfusion may be beneficial in the treatment of overt bleeding from portal-hypertensive gastropathy. In this study gastric mucosal perfusion was assessed in 28 cirrhotic patients with portal-hypertensive gastropathy u...

The objective of present study is to investigate anti-ulcer activity of Artocarpus heterophyllus Lam. leaves extracts on indomethacin induced ulcers in rats and establish the probable mechanism of antiulcer activity, if any and confirm the validity of claims of the activity as mentioned in texts as traditional medicines. The leaves were extracted with methanol and anti-ulcer activity was evalua...