A man in his 70s presented to the emergency unit for hematemesis. His recent blood test showed normal liver and renal function, and serum anti-Helicobacter pylori (H. pylori) IgG antibody was negative. He took neither steroids nor nonsteroidal anti-infl ammatory drugs (NSAIDs). Emergency endoscopy revealed a bleeding gastric ulcer in the greater curvature of the gastric body (Fig. 1A). Endoscop...

RATIONALE The treatment of iron-deficiency anemia with oral iron supplements can present side-effects on the GI tract mucosa including necrosis, ulceration, or ischemia. The particular endoscopic findings and the histopathological exam will establish the diagnosis of erosive gastritis with iron deposits in the gastric mucosa. PATIENT CONCERNS We present the case of a 14-year-old female admitt...

Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for their recurrence. We have previously reported the remarkable gastroprotective and anti-Helicobacter pylori activities of the methanolic extract (CpMet) of Cyrtocarpa procera bark. This work investigates, in a murine model, the CpMet gastroprotective mechanism and establishes its preclini...

The role of oxygen derived free radicals in gastric lesions induced by haemorrhagic shock and the protective effect of oxygen radical scavengers, allopurinol and ranitidine, were investigated. Forty five rabbits underwent haemorrhagic shock for 30 minutes and reinfusion of shed blood. They were killed 30 minutes later. The animals were divided in five groups: A (n = 10): Control, B (n = 10): in...

Video endoscopic images were used to investigate whether gastroenterologists could agree on the definition of lesions within the stomach seen at endoscopy, with particular reference to those seen in patients taking non-steroidal anti-inflammatory drugs. Seven experienced endoscopists, unaware of the patients' clinical history or drug consumption, recorded their classification for 93 randomised ...

Acid intragastric pH is believed to be mandatory for mucosal protective action of sucralfate, but evidence for its efficacy at neutral pH is lacking. The effect of sucralfate on gastric mucosal erosions induced by oral administration of aspirin and bile acids at acidic pH of 1.5 and 3.9, and near neutral pH of 6.5 was investigated in 320 rats. The effect of sucralfate on the intragastric pH fou...

Neurohumoral and psychosomatic factors are now generally regarded as playing an important role in human gastroduodenal ulcer. If these factors are associated with the pathogenesis and recurrence of the ulcer, consideration should be given to a neuro-endocrine mechanism, operating perhaps through the hypothalamus and the pituitary, and the adrenal gland. Many investigators (1, 2, 3, 4, 5, 6) hav...

Serial histological specimens from 14 patients with the endoscopic diagnosis of erosive gastritis and/or duodenitis were examined for correlation between endoscopic and histological findings. All patients were symptomatic outpatients without history of alcoholism or usage of aspirin or nonsteroidal antiinflammatory drugs. After the initial diagnosis, the patients underwent follow-up endoscopy u...

Background/Aims Portal hypertension (PH) is a syndrome characterized by chronic increase in the pressure gradient between the portal vein and inferior vena cava. Previous studies have suggested an increased frequency of antral elevated erosive gastritis in patients with PH, as well as an etiologic association; however, there has not been any histological evidence of this hypothesis to date. Our...

A Peptic ulcer is a mucosal lesion of the stomach or duodenum in which the acid and pepsin play major pathogenic roles. The major forms of peptic ulcer are gastric ulcer and duodenal ulcer, both of which are chronic diseases often caused by Helicobacter pylori. The term peptic ulcer also encompasses gastric ulcers and duodenal ulcers associated with stress or the ingestion of drugs, most common...