A standard method for the production of gastric lesions by aspirin in rats was elaborated, and the mechanisms of the deleterious effects of aspirin were inter preted. The method consisted of pylorus ligation of the rat immediately before as pirin dosing, resulting in severe and consistent gastric lesions in the glandular por tion of the rat stomach 7 hr later. Sodium bicarbonate and L-glutamine...

A crystalline protein having powerful proteolytic activity has been described in previous papers of this series (1). This protein was isolated from commercial pepsin preparations which, in turn, had been prepared from the gastric mucosa of swine, t The possibility exists that this protein was formed from some more complicated compound during the process of extraction and does not represent the ...

Peptic ulcer disease (PUD) is when gastric mucosa gets injured due to the increase of acid and pepsin enzyme. The common risk factors are infection Helicobacter pylori bacteria misused NSAIDs. This review article aims describe role caspase in PUD. Methods used selection articles PubMed. Caspase a protease enzyme that plays an apoptotic inflammatory reaction can be activated dimerized or cleaved...

The molecular structure of human uropepsin, an aspartic proteinase from the urine produced in the form of pepsinogen A in the gastric mucosa, has been determined by molecular replacement using human pepsin as the search model. Crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 50.99, b = 75.56, c = 89.90 A. Crystallographic refinement led to an R factor of 0.161 at 2.45...

Sucralfate, a complex polyaluminium hydroxide salt of polysulphated sucrose, is used in medical treatment of peptic disease as a coating agent that provides a protective barrier to further damage from acid and pepsin. Its actions are principally local and at acid pH becomes highly polar and binds by way of strong electrostatic interaction to ulcer tissue for up to 12 hours, while relatively lit...

Ulcer formation after pylorus ligation was assessed in control, testosterone treated and castrated male rats after cimetidine treatment. The stomach was studied for incidence of ulcers and its contents analysed for pH, volume, total acidity, free acidity, pepsin and mucin activity. Testosterone and cimetidine when used alone protected from ulceration while when used in combination the degree of...

The effects of omeprazole, a substituted benzimidazole, on gastric acid and pepsin secretion have been studied in twelve healthy subjects. From six to eight hours after a single oral dose of 30 mg, there was a 66% reduction in basal acid output, and a 71.2% reduction in pentagastrin stimulated acid output. A single dose of 60 mg produced a 91.7% reduction in basal acid output and a 95.3% reduct...

Numerous recent reports have outlined the clinical profile of childhood peptic ulcer (Alexander, 1951; Fallstrom and Reinand, 1961; Gadiyar, Taneja, and Ghai, 1963; Girdany, 1953; Michener, Kennedy, and Du Shane, 1960; Muggia and Spiro, 1959; Ramirez Ramos, Kirsner, and Palmer, 1960). Investigation of its pathogenesis, however, has not received much attention. There is general agreement that pe...

Normally there is a balance between the protective factors (e.g. mucus, bicarbonate, prostaglandins, nitric oxide and normal blood flow) and aggressive factors (e.g. acid plus pepsin, active oxidants, leukotrienes, endothelins, bile or exogenous factors including nonsteroidal anti-inflammatory drugs). Peptic ulcer develops when aggressive factors overcome the protective mechanisms (Borrelli & I...

Effect of methanolic extract of P. Pinnata roots (PPRM) was studied against various experimental gastric ulcer models and offensive and defensive gastric mucosal factors in rats. An initial dose-response study using 12.5-50 mg/kg P. Pinnata root extract, when given orally in two divided dose for 4 days + 5th full dose on the day of experiment 60 min before the experiment, indicated 25 mg/kg as ...