Acemetacin is the carboxymethyl ester of indomethacin and a pro-drug precursor compound, in other words, prodrug. The pharmacologically active metabolite acemetacin also indomethacin. exerts its potent non-steroidal anti-inflammatory effects body as It known that not only prodrug indomethacin, but an agent with gastric protective mechanisms, possibly involving reduction leukocyte adhesion, by e...

The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with another diterpene, DHC (trans-dehydrocrotonin) in the same models. When previously administered (p.o.)...

The results of earlier studies by my team of researchers demonstrated the wide spectrum of in vivo gastro-protective effects of the methanol extract of Cassia singueana leaves (MECSL) in rats. The crude extract exhibited profound potency against experimentally-induced ulcerative lesions in various gastric ulcer induction models (pyloric ligation/histamine, indomethacin and ethanol-mediated stom...

Pomegranate (Punica granatum L.) belongs to genera Punica and family Punicaceae. It is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. However, to our knowledge, no study has been conducted to evaluate this therapeutic property. In the present study the antiulcerogenic effects of pomegranate peel methanol extract, was tested on male Wistar ...

objective(s):  this study was undertaken to investigate the protective effects of vitamin b6, cofactor for cystathionine-γ lyase and cystathionine-β synthase (producers of h2s), alone and in combination with l-cysteine, h2s precursor, on indomethacin-, and ethanol-induced gastric lesions in male nmri mice. materials and methods: fasted male nmri mice were randomly assigned into 12 groups (7 in ...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in Egyptian traditional medicine to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage),...

This study assessed the gastric acid antisecretory effect of DLBS2411 fractionated from Cinnamomum burmannii. Hydrogen potassium adenosine triphosphatase (H(+)/K(+) ATPase) activity and its gene expression were observed, and the antioxidant activity of DLBS2411 was also investigated. Treatment of DLBS2411 decreased the level of H(+)/K(+) ATPase messenger RNA expression on human embryonic kidney...

BACKGROUND/AIMS The effect of kefir on peptic ulcer disease was evaluated in an experimental model, with non-steroid anti-inflammatory drugs, together with the determination of gastric mucus secretion by quantitative digital histochemistry. MATERIALS AND METHODS The experimental group included 28 male albino Wistar rats. After a diet with standard rat bait for 7 days, 14 rats were fed with ke...

objective: gut–brain axis (gba) is very important in creation and modulation of gastrointestinal problems. aloe vera gel has gastroprotective properties. the purpose of this study was to evaluate the effect of aqueous extract of aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction. materials and methods: gastric ulce...

BACKGROUND/AIMS The effects of anti-ulcerogenic drugs are dependent on the increase in prostaglandin production and reduction in leukotriene production in the gastric mucosa. Montelukast is an anti-asthmatic drug, a selective reversible cysteinyl leukotriene D4 receptor antagonist. In this study, we aimed to evaluate the anti-ulcerogenic effect of montelukast and to investigate the relationship...