This study aimed to investigate the possible gastroprotective effect of tocotrienol against water-immersion restraint stress (WIRS) induced gastric ulcers in rats by measuring its effect on gastric mucosal nitric oxide (NO), oxidative stress, and inflammatory biomarkers. Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered v...

In this study, the antiulcerogenic effect of essential oil from Baccharis dracunculifolia was evaluated using the model of acute gastric lesions induced by ethanol. The ulcerative lesion index (ULI) was significantly reduced by oral administration of the essential oil of B. dracunculifolia at doses of 50, 250 and 500 mg/kg which reduced the lesions by 42.79, 45.70 and 61.61%, respectively. The ...

The aim of this work was to prepare a combined drug dosage form of famotidine (FAM) and quercetin (QRT) to augment treatment of gastric ulcer. FAM was prepared as freeze-dried floating alginate beads using ion gelation method and then coated with Eudragit RL100 to sustain FAM release. QRT was prepared as solid dispersion with polyvinyl pyrrolidone K30 to improve its solubility. Photo images and...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in Egyptian traditional medicine to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage),...

Daemia extensa is a well-known traditional plant in India. The plant is having laxative, anthelmintic, astringent, Immunosuppressive, potent antioxidant, in-vitro antibacterial and antifungal activity. The aim was to search for anti-ulcer activity of ethanolic extract of Daemia extensa seed. Ethanolic extract of Daemia extensa seed was considered for its potential to protect gastric mucosa agai...

Aim. The side effects associated with the use of indometacin are noted by about 30-60% patients, therefore, in this context problem adverse event rate reduction is still relevant today. Cryopreserved placental extract (CEP) attracted our attention as a means pathogenetic correction ulcerogenic action indomethacin. aim paper to characterize antiulcer activity cryopreserved placenta on model indo...

Acanthus ilicifolius (Acanthaceae), a mangrove medicinal plant, is widely used by the local inhabitants of the Sundarbans (India) to treat a variety of diseases. As a part of our continued search for novel bioactive products from mangrove medicinal plants, we were able to document the anti-inflammatory effects of this plant. In the present study, we have performed a detailed evaluation of the g...

Objectives: Free radicals generation, inflammation, and nitric oxide (NO) modulation are involved in indomethacin (IND)-induced gastric ulcers. Most of the drugs used for the treatment of gastric ulcer have various side effects. Genistein (GEN), the natural isoflavones isolated from soya bean has an antioxidant, anti-inflammatory, and NO modulating activity. These properties could make GEN a pr...

Ulcers are the most common form of GI disorder that is often caused by either inflammation or infection that certainly affected 10% of the population at risk. Among all types of ulcers, peptic ulcer is the more catastrophic one. This point made an exemption objective to conduct an investigation for antiulcer activity of alcoholic extract of Garuga pinnata leaves in rats. Acute gastric lesions i...

The study was designed to determine the gastroprotective and ulcer healing efficacy of basic transforming growth factor (bFGF) and to assess whether this peptide contributes to the action of sucralfate on the rat stomach. Application of human recombinant bFGF (1-100 micrograms/kg/hour subcutaneously) failed to affect the formation of acute gastric lesions induced by 100% ethanol and acidified a...