Gastric cancer is the third leading cause of cancer-related mortality worldwide. Despite progress in understanding its development, challenges with treatment remain. Gastrin, a peptide hormone, is trophic for normal gastrointestinal epithelium. Gastrin also has been shown to play an important role in the stimulation of growth of several gastrointestinal cancers including gastric cancer. We soug...

The gastric hormone gastrin regulates the expression of a variety of genes involved in control of acid secretion and also in the growth and organization of the gastric mucosa. One putative target is plasminogen activator inhibitor-2 (PAI-2), which is a component of the urokinase activator system that acts extracellularly to inhibit urokinase plasminogen activator (uPA) and intracellularly to su...

Kosaka and Lim (1930) demonstrated that extracts from the upper intestine would inhibit gastric secretion from dogs with Heidenhain pouches. The degree of inhibition produced was similar to that observed after the oral ingestion of fat. Similar doses of the extract were shown to have no effect on either pancreatic or biliary secretion. Gillespie and Grossman (1964) have demonstrated that cholec...

BACKGROUND A randomized prospective study on the response of fasting serum gastrin concentrations in peptic ulcer patients was performed in order to test the hypothesis that H. pylori infection in the gastric antrum increases gastrin release, and to examine whether the high fasting serum gastrin concentrations respond to treatment that eradicates H. pylori. METHODS One hundred and twenty-seve...

normal 0 false false false en-us x-none ar-sa background: gastric carcinoma is the second most common cause of cancer-related death in iran. it is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin 17 (g-17), pepsinogen i (p-i), and pepsinogen ii (p-ii). the aim of this study was to investigate the diagnostic ac...

(a) It is not clear what gastrin species were measured in their assay system. Many authors have shown that when confounding factors such as Helicobacter pylori infection and use of proton pump inhibitors are taken into account, there is no rise in amidated gastrin levels [Penman et al. (1) and Ciccotosto et al. (2)]. However immature forms of gastrin, such as progastrin, are increased in colore...

We have used a specific deoxyoligonucleotide probe to detect gastrin mRNA in poly(A)-enriched RNA preparations from hog antrum. The nucleotide sequence of the oligonucleotide, d(C-T-C-C-T-C-C-A-T-C-C-A), was deduced from the unique amino acid sequence Trp-Met-Glu-Glu of gastrin. When used with hog antral RNA, the dodecanucleotide is an effective primer for the synthesis of gastrin-specific cDNA...

Adrenocorticotropin (ACTH)-like and alpha-melanotropin (alpha-MSH)-like peptides have been localized to a subpopulation of cytoplasmic (secretory) granules of human antropyloric gastric cells and of fetal and neoplastic gastrin cells. These granules also store gastrin and belong to the electron-dense variety of gastrin cell granules. Gastrin cells also contain granules of low to medium electron...

Mutations in the MEN1 gene correlate with multiple endocrine neoplasia I (MEN1). Gastrinomas are the most malignant of the neuroendocrine tumors associated with MEN1. Because menin and JunD proteins interact, we examined whether JunD binds to and regulates the gastrin gene promoter. Both menin and JunD are ubiquitous nuclear proteins that we showed colocalize in the gastrin-expressing G cells o...

Radioimmunoassays have recently made it possible to measure the concentration of gastrin in human plasma (Hansky and Cain, 1969; Byrnes, Young, Chisholm, and Lazarus, 1970; McGuigan and Trudeau, 1970; Yalow and Berson, 1970). It has been shown that the plasma gastrin rises in response to such stimuli as the ingestion of food and insulin hypoglycaemia. However, little is known about any quantita...