BACKGROUND Visceral hyperalgesia is a hallmark of functional gastrointestinal disorders. Antidepressants improve symptoms in these patients, although their mode of action is unclear. Antidepressant, anticholinergic, and analgesic mechanisms have been proposed. AIMS To investigate whether imipramine, which has a visceral analgesic effect, increases pain thresholds to experimental visceral pain...

introduction: ramadan is the ninth month of muslim's calendar during which muslims fast. ramadan lasts 29-30 days based on the visual sightings of the crescent moon. fasting during ramadan has significant health effects. the present study aimed at reviewing the literature of the impact of ramadan fasting on upper gastrointestinal disorders. results: gastric acid and pepsin secretion increa...

background : the purpose of this study was to determine reliability and construct validity of a persian version of the gastrointestinal symptoms rating scale (gsrs) in 2 samples of patients with functional gastrointestinal disorders (fgid) and healthy persons. materials and methods : the clinical sample consisted of 143 patients diagnosed with fgid who were referred to the psychosomatic disorde...

background: the purpose of this study was to compare alexithymia, anxiety, depression and severity of gastrointestinal symptoms in patients with functional gastrointestinal disorders and psychiatric patients. materials and methods: this was a comparative study. study subjects consisted of 210 individuals; 129 patients with functional gastrointestinal disorders (fgid) who referred to the psychos...

esophaggogastroduodenoscopy

determination of normal gastric emptying time and small intestinal transit time are useful in detecting gastrointestinal motility disorders and partial obstructions of the pylorus or small intestine. this study was conducted to evaluate iodixanol as a contrast agent in the gastrointestinal tract in new zealand white rabbit. twelve clinically healthy adult rabbits were prepared and kept for two ...

FOR PATIENTS WITH MUSCULOskeletal disorders, convent ional nonsteroidal anti inflammatory drugs (NSAIDs) are a mainstay of clinical care. Wellestablished limitations of NSAID therapy, however, include the risk of developing significant injury to the upper gastrointestinal (GI) tract. The annualized incidence rate of symptomatic GI ulcers and ulcer complications in NSAID users ranges from 2% to ...