Generalized Benders decomposition (GBD) is a globally optimal algorithm for mixed integer nonlinear programming (MINLP) problems, which are NP-hard and can be widely found in the area of wireless resource allocation. The main idea GBD decomposing an MINLP problem into primal master problem, iteratively solved until their solutions converge. However, direct implementation time- memory-consuming....

Small molecule drug discovery requires constant innovation The exhaustive enumeration of the 26.4 million possible small organic molecules up to 11 atoms of C, N, O, F in the database GDB shows that 99.8 percent of the small molecule chemical space has yet to be explored. Guided by virtual screening tools, a proof-of-principle study shows that novel bioactive ligands from GBD can be readily ide...

A clinical case--a follow-up clinical and histological study--is presented in this paper, which describes the use of resorbable hydroxylapatite [OsteoGen (H.A. Resorb), Impladent, Inc., & GBD Marketing Group, Inc., Medical Division, Valley Stream, NY 11580] for the repair of a large mandibular lesion, followed by the placement of an endosseous dental implant six weeks after the graft placement....

This paper describes a backplane transceiver, which uses pulse amplitude modulated four-level (PAM-4) signaling and continuously adaptive transmit-based equalization to move 2.5-GBd/s symbols totalling 5 Gb/s across typical FR-4 backplanes for total distances of up to 50 inches through two sets of backplane connectors. The 17-mm device is implemented in a 0.25m CMOS process, operates off of 2.5...

In this article, we report on the modeling, design, and characterization of indium phosphide (InP) double heterojunction bipolar transistor (DHBT) devices integrated circuits (ICs) for next-generation optical communications. Critical aspects transistors’ modeling their influence IC design are detailed, as well a lumped linear modulator driver featuring 3-Vppd four-level pulse-amplitude modulati...

the editorial by jeremy shiffman, “knowledge, moral claims and the exercise of power in global health”, highlights the influence on global health priority-setting of individuals and organizations that do not have a formal political mandate. this sheds light on the way key functions in global health depend on private funding, particularly from the bill & melinda gates foundation.