BACKGROUND Corticosteroid resistance is a major barrier to effective treatment of COPD. We have shown that the resistance is associated with decreased expression of glucocorticoid receptor (GCR) by senescent CD28nullCD8+ pro-inflammatory lymphocytes in peripheral blood of COPD patients. GCR must be bound to molecular chaperones heat shock proteins (Hsp) 70 and Hsp90 to acquire a high-affinity s...

We present a Weierstrass-type representation formula which locally represents every regular two-dimensional lightlike surface in Lorentz-Minkowski 4-Space $\mathbb{M}^4$ by three dual functions $(\rho,f,g)$ and generalizes the for surfaces $\mathbb{M}^3$. give necessary sufficient conditions on $\rho$, $f$, $g$ to be minimal, ruled or $l$-minimal. For surfaces, we itself ruled. Furthermore, res...

Abstract Both the recent 2009 and 2020 solar minima were classified as unusually quiet characterized with high galactic cosmic-ray (GCR) levels. However, unlike trends from previous decades, in which anomalous (ACR) GCR levels strongly agreed, ACR intensities did not reach such high, record-setting This discrepancy between behavior of GCRs ACRs is investigated this work by simulating accelerati...

We investigate the collision of adhesive viscoelastic spheres in quasistatic approximation where the adhesive interaction is described by the Johnson, Kendall, and Roberts (JKR) theory. The collision dynamics, based on the dynamic contact force, describes both restitutive collisions quantified by the coefficient of restitution epsilon as well as aggregative collisions, characterized by the crit...

We consider a sequence of quantum states, $\rho_N$, associated with submanifold $\Lambda$ product two integral compact Kahler manifolds. show that, when is submanifold, then, in the semiclassical limit, these states are not entangled. discuss whether geometry (specifically being submanifold) has any relationship entanglement properties $\rho_N$.

In this paper we study curvature properties of semi - symmetric type of totally umbilical radical transversal lightlike hypersurfaces $(M,g)$ and $(M,widetilde g)$ of a K"ahler-Norden manifold $(overline M,overline J,overline g,overline { widetilde g})$ of constant totally real sectional curvatures $overline nu$ and $overline {widetilde nu}$ ($g$ and $widetilde g$ are the induced metrics on $M$...

Using the Langley Research Center galactic cosmic ray (GCR) transport computer code (HZETRN) and the computerized anatomical man (CAM) model, crew radiation levels inside manned spacecraft on interplanetary missions are estimated. These radiation-level estimates include particle fluxes, LET (linear energy transfer) spectra, absorbed dose, and dose equivalent within various organs of interest i...

Suppose G is a second countable, locally compact, Hausdorff groupoid with a fixed left Haar system. Let G/G denote the orbit space of G and C∗(G) denote the groupoid C∗-algebra. Suppose that the isotropy groups of G are amenable. We show that C∗(G) is CCR if and only if G/G is a T1 topological space and all of the isotropy groups are CCR. We also show that C∗(G) is GCR if and only if G/G is a T...

Determining the appropriate number and position of waypoints on a great circle route (GCR) helps to shorten sailing distance, reduce course changes, well-approximate GCR through small rhumb line (RL) legs. In this study, genetic algorithm-based method (i.e., GA method) is proposed optimize positions when given. Furthermore, fuzzy logic-based evaluation for FL judge whether add new waypoint or s...

Version 1b, June 2008 The fracpole suite is a collection of programs used to generate Spectre subcircuits that model components that require a fractional pole impedance. The suite includes a program for generating the fractional pole impedance itself, a program for generating models of inductors that include skin effect, and a program that generates models of capacitors that include dielectric ...