نتایج جستجو برای: gem tv

تعداد نتایج: 20064  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Wainer Zoli Luca Ricotti Anna Tesei Paola Ulivi Anna Gasperi Campani Francesco Fabbri Roberta Gunelli Giovanni Luca Frassineti Dino Amadori

PURPOSE The aim of the study was to evaluate the activity of epidoxorubicin (EPI) and gemcitabine (GEM) and to define the most effective schedule in human bladder cancer cells. EXPERIMENTAL DESIGN The study was performed on HT1376 and MCR cell lines. Cells were exposed for 1 and 24 h to drugs used in different schemes. Cytotoxic activity was evaluated by the sulforhodamine B assay, potential ...

2013
Assaad Nasr El Dine Ali Khalaf Danielle Grée Olivier Tasseau Fares Fares Nada Jaber Philippe Lesot Ali Hachem René Grée

Starting from easily accessible gem-difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem-difluoroalkyl chain. These derivatives were used to prepare pyrazolines and pyrrolines with the desired gem-difluoroalkyl side chain by cyclocondensations in good yields and with excellent stereoselectivity. A one-pot process was also successfully developed ...

Journal: :HortScience 2014

Kasmaee, Elahe ,

Purpose: The present article aims to examine the effect of media on students' mental and psychological health in the process of culture-building by the Baharestan TV of Tajikistan. Methodology: The study has been carried out by providing examples such as visual culture, media philosophy, child TV and culture-building. This research studies the culture-building practices of Baharestan TV and gen...

Journal: :Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011
Chang-Peng Zhu Jian Shi Yue-Xiang Chen Wei-Fen Xie Yong Lin

AIMS Whether gemcitabine based chemoradiotherapy (GEM-based CRT) is superior to 5-fluorouracil based chemoradiotherapy (5-FU-based CRT) for locally advanced pancreatic cancer (LAPC) remains uncertain. The aim of the present study was to evaluate the effect of GEM-based CRT compared with 5-FU-based CRT. METHODS Electronic database including Medline, Embase, Cochrane controlled trials register,...

Journal: :The Journal of biological chemistry 2004
Fumitaka Oyama Svetlana Kotliarova Akihiro Harada Mamoru Ito Haruko Miyazaki Yoshito Ueyama Nobutaka Hirokawa Nobuyuki Nukina Yasuo Ihara

A series of observations have indicated that tau, one of the major microtubule-associated proteins, is involved in neuronal cell morphogenesis and axonal maintenance. Tau is also the major component of paired helical filaments found in brains affected by Alzheimer's disease. To explore an as yet unidentified role of tau in vivo, approximately 11,000 mRNAs were profiled from tau-deficient mouse ...

2017
Shuqin Ni Lei Qiu Guodong Zhang Haiyan Zhou Yong Han

PURPOSE Radiation and chemotherapy are the most common course of treatment for B-cell lymphoma. Doxorubicin (DOX), gemcitabine (GEM), and vincristine (VCR) are the commonly used antilymphoma chemotherapeutic drugs. The aim of this study is to construct a novel drug delivery system for the combination delivery of the three drugs on lymphoma. MATERIALS AND METHODS DOX-GEM prodrug was synthesize...

Journal: :Oncology reports 2007
Masatoshi Kanzaki Hideaki Kakinuma Teruaki Kumazawa Takamitsu Inoue Mitsuru Saito Shintarou Narita Takeshi Yuasa Norihiko Tsuchiya Tomonori Habuchi

Histone deacetylase inhibitors (HDACis) have been developed as a new type of drug for cancer treatment. In this study, we examine the augmentation efficacy of depsipeptide (FK228) in combination with gemcitabine (GEM) or docetaxel (DOC) in vitro and in vivo against hormone refractory prostate cancer (HRPC). The anti-proliferative effects, cell cycle distribution and apoptotic status were assess...

2015
Shinsuke Nakashima Shogo Kobayashi Hiroaki Nagano Akira Tomokuni Yoshito Tomimaru Tadafumi Asaoka Naoki Hama Hiroshi Wada Koichi Kawamoto Shigeru Marubashi Hidetoshi Eguchi Yuichiro Doki Masaki Mori

The BRCA/Fanconi anemia (FA) pathway plays a key role in the repair of DNA double strand breaks. We focused on this pathway to clarify chemoresistance mechanisms in biliary tract cancer (BTC). We also investigated changes in the CD24(+)/44(+) population that may be involved in chemoresistance, as this population likely includes cancer stem cells. We used three BTC cell lines to establish gemcit...

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