We have previously shown that the regulation by interleukin-1b (IL-1b) of inducible nitric oxide synthase (iNOS) involves phospholipase A2 (PLA2) metabolites in neonatal ventricular myocytes. Based on studies in which ONO-RS-082 is used to inhibit secretory PLA2 and methyl arachidonyl fluorophosphonate is used to inhibit cytosolic PLA2, our data suggest that a secretory PLA2 metabolite was invo...

Interleukin 8 (II.-K) inKNA was detected in peripheral leukemic cells obtained from adult T-cell leukemia patients, as well as in cultured human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines (HUT-102, MT-1, SALT-3, and SKT-1B). With the use of ELISA, IL-8 protein was also detected in the culture medium of these cells and in the extracellular fluids of patients. Furthermore, we dem...

t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...

Objective(s): It is now supposed that cytokines released during the burn injuries have a great impact on the immunological and pathological responses after the burn. The main objective of this study was to investigate the expression of some pro-inflammatory genes in the wound, spleen and blood neutrophils during the healing process of burn wounds in a murine model. Materials and Methods: The ex...

background: il-10 is an anti-inflammatory cytokine which is involved in tumorigenesis. over production of il-10 and elevated number of il-10 generating mononuclear cells in breast tumor tissue has already been shown. objective: to determine the association of il-10 promoter polymorphisms with increased risk of breast cancer and its association with breast cancer prognostic factors. methods: per...

Layé, Sophie, Gilles Gheusi, Sandrine Cremona, Chantal Combe, Keith Kelley, Robert Dantzer, and Patricia Parnet. Endogenous brain IL-1 mediates LPSinduced anorexia and hypothalamic cytokine expression. Am J Physiol Regulatory Integrative Comp Physiol 279: R93– R98, 2000.—The present study was designed to determine the role of endogenous brain interleukin (IL)-1 in the anorexic response to lipop...

Layé, Sophie, Gilles Gheusi, Sandrine Cremona, Chantal Combe, Keith Kelley, Robert Dantzer, and Patricia Parnet. Endogenous brain IL-1 mediates LPSinduced anorexia and hypothalamic cytokine expression. Am J Physiol Regulatory Integrative Comp Physiol 279: R93– R98, 2000.—The present study was designed to determine the role of endogenous brain interleukin (IL)-1 in the anorexic response to lipop...

Background: Endometriosis is the growth of endometrial cells outside the uterine cavity. It has been suggested that immune system plays important roles in both initiation and progression of the disease. Several studies have been shown that women with endometriosis diverge in their expression of different genes including heat-shock proteins, fibronectin, and neutrophil elastase, which might be i...

background: cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors and is one of the cancer treatment strategies. recently, interluekin36 (il36) has been used as immunotherapeutic agents in cancer gene therapy. present study investigated that the il36 gene therapy effects on the regression of tumor masses in mouse model. aim of this study is determination of t...

background and purpose: hila-g is an immunomodulatory molecule and alteration of its expression is prevalent during viral infections. hla-g expression in hiv-positive patients has been inconsistent between different studies and some suggest that interleukin-10 (il-10) influences the expression of hla-g. the aim of this research was to investigate the expression of il-10 in hiv-positive patients...