Genome-wide, high-throughput methods for transcription start site (TSS) detection have shown that most promoters have an array of neighboring TSSs where some are used more than others, forming a distribution of initiation propensities. TSS distributions (TSSDs) vary widely between promoters and earlier studies have shown that the TSSDs have biological implications in both regulation and functio...

In this paper some upper and lower bounds for the greatest eigenvalues of the PI and vertex PI matrices of a graph G are obtained. Those graphs for which these bounds are best possible are characterized.

conclusions the relatively high prevalence of percutaneous injuries and splashes in this study emphasized the importance of improved prevention strategies, better hospital surveillance for occupational exposure, and enhanced training of healthcare workers. background healthcare workers (hcws) regularly face the risk of exposure to sharp injuries and splashes as an occupational hazard, which pre...

Weirs have widely been used for the flow measurement, flow diversion and its control in the open channels. Attempts have been made to study flow over different shapes of normal weirs, side weirs and oblique weirs. This paper is connected with the development of the discharge coefficient measurement. In the present study four different weirs in different height are considered for validation purp...

weirs have widely been used for the flow measurement, flow diversion and its control in the open channels. attempts have been made to study flow over different shapes of normal weirs, side weirs and oblique weirs. this paper is connected with the development of the discharge coefficient measurement. in the present study four different weirs in different height are considered for validation purp...

background and objectives: exposure to contaminated needlesticks and sharp devices is an important occupational hazard among healthcare workers. the objective of this study was to gain further insight into prevalence and risk factors of needlestick and sharps injuries among healthcare workers. methods: a cross-sectional survey was carried out among 384 healthcare workers of two hospitals in ne...

Core promoters are crucial for gene regulation, providing blueprints for the assembly of transcriptional machinery at transcription start sites (TSSs). Empirically, TSSs define the coordinates of core promoters and other regulatory sequences. Thus, experimental TSS identification provides an essential step in the characterization of promoters and their features. Here, we describe the applicatio...

Transcription factors control gene expression by binding to short specific DNA sequences, called transcription factor binding sites (TFBSs), in the promoter of a gene. Thus, studying the spatial distribution of TFBSs in the promoters may provide insights into the molecular mechanisms of gene regulation. I developed a method to construct the spatial distribution of TFBSs for any set of genes of ...