Abstract Antituberculosis drug‐induced liver injury (ATDILI) has received increasing attention globally, which may limit the effectiveness of antituberculosis (anti‐TB) treatment. Many host genetic determinants ATDILI have been identified recently. As little knowledge is currently available about association between aldehyde dehydrogenase 1 family member A1 (ALDH1A1) polymorphisms and ATDILI, t...

Each day, approximately 27,000 people become ill with tuberculosis (TB), and 4,000 die from this disease. Pulmonary TB is the main clinical form of TB, affects lungs a considerably heterogeneous manifestation among patients. Immunomodulation by an interplay host-, environment-, pathogen-associated factors partially explains such heterogeneity. Microbial communities residing in host's airways ha...

Definitive diagnosis of tuberculosis (TB) by conventional culture, followed by bacterial identification based on biochemical tests is time-consuming and tedious. Simple loop-mediated isothermal amplification (LAMP) specific for Mycobacterium tuberculosis complex, targeting the M. tuberculosis 16S ribosomal RNA gene, termed TB-LAMP, was evaluated as an alternative for rapid culture confirmati...

Background: Tuberculosis (TB) is a major global cause of mortality and morbidity, and host genetic factors influence disease susceptibility. Interferon-c mediates immunity to mycobacteria and rare mutations in the interferon-c receptor-1 gene (IFNGR1) result in increased susceptibility to mycobacterial infection, including TB, in affected families. The role of genetic variation in IFNGR1 in sus...

objective: despite using the bacille calmette guerin (bcg) vaccine, tuberculosis (tb) is still a worldwide disease that kills 2-3 million people each year. developing a new and more effective vaccine is one way to possibly reduce the morbidity and mortality of tb. the mtb72f vaccine is one of the important subunit vaccines applied in human clinical trials. in this study, we have constructed an ...

Abstract Short-chain fatty acids, especially butyrate, play beneficial roles in sustaining gastrointestinal health. However, due to limitations associated with direct consumption of there has been interest using prodrugs butyrate. Tributyrin (TB), a triglyceride composed three butyrate molecules and glycerol, is well-studied precursor We screened metagenome library consisting 5760 bacterial art...

The Mycobacterium tuberculosis (M. tb) antigens encoded by the 6 kDa early secretory antigenic target (esat-6) and antigen 85A (ag85a) genes are known to exert protective effects against tuberculosis in animal models. In addition, these antigens represent vaccine components that were tested in early human clinical trials. In the present study, a chimeric DNA vaccine was constructed that contain...

background epidemiological information on tuberculosis (tb) is required to plan control and prevention strategies and to inform service delivery systems. the aim of present study was to determine the epidemiological status of tb in hamadan province covering a seven-year period.   methods in this cross-sectional study all registered tb patients suffering from any form of smear-positive, smear-ne...

In latent tuberculosis infection (LTBI) spread of the bacteria is contained by a persistent immune response, which includes CD4(+) T cells as important contributors. In this study we show that TB-specific CD4(+) T cells have a characteristic chemokine expression signature (CCR6(+)CXCR3(+)CCR4(-)), and that the overall number of these cells is significantly increased in LTBI donors compared with...