an f2 japanese quail population was developed by crossing two strains (wild and white) to map quantitative trait loci (qtl) for performance and carcass traits. a total of 472 f2 birds were reared and slaughtered at 42 days of age. performance and carcass traits were measured on all of the f2 individuals. parental (p0), f1 and f2 individuals were genotyped with 3 microsatellites from quail chrom...

Basics of Linkage and Gene Mapping ......................................................................45 Linkage....................................................................................................................45 Linkage disequilibrium ............................................................................................47 Mapping functions ..............................

Cells with the same genotype growing under the same conditions can show different phenotypes, which is known as "population heterogeneity". The heterogeneity of hematopoietic progenitor cells has an effect on their differentiation potential and lineage choices. However, the genetic mechanisms governing population heterogeneity remain unclear. Here, we present a statistical model for mapping the...

We demonstrate a method for developing populations suitable for genome-wide high-resolution genetic linkage mapping, by recurrent intermating among F2 individuals derived from crosses between homozygous parents. Comparison of intermated progenies to F2 and "recombinant inbred" (RI) populations from the same pedigree corroborate theoretical expectations that progenies intermated for four generat...

Dissecting quantitative genetic variation into genes at the molecular level has been recognized as the greatest challenge facing geneticists in the twenty-first century. Tremendous efforts in the last two decades were invested to map a wide spectrum of quantitative genetic variation in nearly all important organisms onto their genome regions that may contain genes underlying the variation, but ...

There has been a great deal of interest in the development of methodologies to map quantitative trait loci (QTL) using experimental crosses in the last 2 decades. Experimental crosses in animal and plant sciences provide important data sources for mapping QTL through linkage analysis. The Collaborative Cross (CC) is a renewable mouse resource that is generated from eight genetically diverse fou...

of Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy BAYESIAN FUNCTIONAL MAPPING OF COMPLEX DYNAMIC TRAITS By Tian Liu August 2007 Chair: Rongling Wu Major: Statistics Many quantitative traits of fundamental importance to agricultural, evolutionary, and biomedical genetic research can bett...