Motivation Genomics features with similar genome-wide distributions are generally hypothesized to be functionally related, for example, colocalization of histones and transcription start sites indicate chromatin regulation of transcription factor activity. Therefore, statistical algorithms to perform spatial, genome-wide correlation among genomic features are required. Results Here, we propos...

Meta-analysis techniques have been widely developed and applied in genomic applications, especially for combining multiple transcriptomic studies. In this paper, we propose an order statistic of p-values (rth ordered p-value, rOP) across combined studies as the test statistic. We illustrate different hypothesis settings that detect gene markers differentially expressed (DE) "in all studies", "i...

Today, with the growth of technology, monitoring processes by the use of video and satellite sensors have been more expanded, due to their rich and valuable information. Recently, some researchers have used sequential images for image defect detection because a single image is not sufficient for process monitoring. In this paper, by adding the time dimension to the image-based process monitorin...

Genomic copy number alteration and allelic imbalance are distinct features of cancer cells, and recent advances in the genotyping technology have greatly boosted the research in the cancer genome. However, the complicated nature of tumor usually hampers the dissection of the SNP arrays. In this study, we describe a bioinformatic tool, named GIANT, for genome-wide identification of somatic aberr...

The method of statistical differentials, which approximates the mean value and variance of transformations of random variables is used in many areas of mathematics. This paper will discuss the conditions under which such an approximation will be exact, and also explore their accuracy in terms of error bounds under certain moment conditions. AMS SUBJECT CLASSIFICATION (2000): 40A05, 41A10, 41A25...

Previous studies have shown that the identification and analysis of both abundant and rare k-mers or "DNA words of length k" in genomic sequences using suitable statistical background models can reveal biologically significant sequence elements. Other studies have investigated the uni/multimodal distribution of k-mer abundances or "k-mer spectra" in different DNA sequences. However, the existin...

Functional genomic quantities such as histone modifications, chromatin accessibility, and evolutionary constraint can now be measured in a nearly continuous fashion across the genome. The genome is highly heterogeneous, and the relationships between different functional annotations may be fluid. Here we present an approach for visualizing, quantifying, and determining the statistical significan...

Association between disease and genetic polymorphisms often contributes critical information in our search for the genetic components of common diseases. Devlin and Roeder [1999: Biometrics 55:997-1004] introduced genomic control, a statistical method that overcomes a drawback to the use of population-based samples for tests of association, namely spurious associations induced by population str...

The availability of dense molecular markers has made possible the use of genomic selection in plant and animal breeding. However, models for genomic selection pose several computational and statistical challenges and require specialized computer programs, not always available to the end user and not implemented in standard statistical software yet. The R-package BLR (Bayesian Linear Regression)...

This paper presents a statistical method to match feature points from stereo pairs of images. The proposed method is evaluated in terms of effectiveness, robustness and computational speed. The evaluation was performed on several pairs of real stereo images of natural scenes taken onboard an unmanned aerial vehicle. The results show that the proposed method reduces the number of incorrect match...