نتایج جستجو برای: gestational trophoblastic diseases

تعداد نتایج: 883355  

Journal: :International journal of reproduction, contraception, obstetrics and gynecology 2023

Invasive mole is a rare gestational trophoblastic neoplasia with proliferative trophoblast invading into myometrium or uterine vasculature. Primary management of invasive chemotherapy, but hysterectomy can be performed in selective cases. In this report, we discuss two cases mole, which required surgical intervention the form hysterectomy. Both patients had favorable outcome and are remission.

2015
Mei Peng Yiling Ding Ling Yu Yali Deng Weisi Lai Yun Hu Hongwen Zhang Xianqing Wu Hong Fan Hui Ding Yilin Wu Guangshi Tao Xing Xie

Although 5-fluorouracil (5-Fu) combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs), it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D) vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 ...

Journal: :Radiographics : a review publication of the Radiological Society of North America, Inc 2009
Khaled M Elsayes Andrew T Trout Aaron M Friedkin Peter S Liu Ronald O Bude Joel F Platt Christine O Menias

The placenta is often overlooked in the routine evaluation of a normal gestation, receiving attention only when an abnormality is detected. Although uncommon, abnormalities of the placenta are important to recognize owing to the potential for maternal and fetal morbidity and mortality. Pathologic conditions of the placenta include placental causes of hemorrhage, gestational trophoblastic diseas...

2017
Xiaoyu Wang Junjun Yang Jie Li Jun Zhao Tong Ren Fengzhi Feng Xirun Wan Yang Xiang

PURPOSE To evaluate the oncological safety and pregnant outcomes of fertility-sparing uterine lesion resection in treating gestational trophoblastic neoplasias. RESULTS After the treatment of surgery and chemotherapy, all the patients achieved complete remission. With a median follow-up time of 44 months (range, 6-188), 3 patients (3.85%) relapsed within 3-26 months. Multivariate analysis sho...

Journal: :International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2012
Azamsadat Mousavi Fatemeh Cheraghi Fariba Yarandi Mitra Modaress Gilani Hadi Shojaei

OBJECTIVE To determine the effectiveness of 2 standard chemotherapy regimens for low-risk gestational trophoblastic disease according to the International Federation of Gynecology and Obstetrics (FIGO) staging system. METHODS From 2008 until 2010, 75 women with low-risk gestational trophoblastic disease received either pulsed actinomycin D (n=50) or 5-day methotrexate (n=25). The primary remi...

2014
Joanna Ho Yanan Du Oscar Gee-Wan Wong Michelle K. Y. Siu Karen K. L. Chan Annie N. Y. Cheung Kelvin Yuen Kwong Chan

The kinesin protein Kif7 has been recognized as an integral component of hedgehog signalling. Aberrant activation of hedgehog signalling has been implicated in many human solid tumours. Gestational trophoblastic disease includes frankly malignant choriocarcinoma and potentially malignant hydatidiform mole. Here we investigated the hedgehog signalling components expression profiles in gestationa...

Journal: :International Journal of Reproduction, Contraception, Obstetrics and Gynecology 2020

Journal: :Clinical Obstetrics, Gynecology and Reproductive Medicine 2016

Journal: :International Journal of Community Medicine and Public Health 2021

Various forms of trophoblastic diseases were reported in the literature, including complete and partial hydatidiform moles, gestational choriocarcinomas, placental-site epitheloid tumors. Among patients who suffer from mole, neoplasia can be easily diagnosed by using levels human chorionic gonadotropin (hCG). Therefore, complex investigations are not usually necessary measuring hCG, physical ex...

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