PURPOSE To evaluate the impact of primary Gleason grade in Gleason score (GS) 7 prostate cancer on biochemical recurrence (BCR) after radical prostatectomy in Korean men. MATERIALS AND METHODS We retrospectively reviewed records of 1,026 patients who underwent radical prostatectomy at Seoul National University Bundang Hospital between November 2003 and June 2009. We excluded patients who had ...

Alterations in the PIK3CA and PTEN genes were assessed in 40 prostate tumors (radical prostatectomy samples). Genetic analyses in glands of the highest Gleason pattern within each tumor revealed PIK3CA amplification in 13%, PIK3CA mutations in 3%, PTEN homozygous deletion in 13% and PTEN hemizygous deletion in 8% of the cases analyzed. Supporting the view that PTEN and PIK3CA act in the same PI...

INTRODUCTION Recent evidence from histology studies regarding random prostate biopsies hint toward a relationship between higher biopsy Gleason score and the development of metastatic castration resistant prostate cancer (mCRPC). However, prostate biopsy underestimates final pathology in about one-third of patients. We evaluated the final whole gland pathology from radical prostatectomy exclusi...

ARTICLE INFO ______________________________________________________________ ______________________ Objective: Histological details of positive surgical margins in radical prostatectomy specimens have been related to outcome after surgery in rare studies recently published. Our objective is to assess whether the status of surgical margins, the extent and the Gleason score of positive margins, an...

The Gleason score is one of a number of factors used in staging patients diagnosed with prostate cancer and in determining the treatment path such patients will ultimately follow. However, discrepancies in the Gleason scores obtained through biopsy compared with the final pathological staging of specimens following radical prostatectomy are not uncommon. Incorrect Gleason scoring can potentiall...

The aim of this study was to investigate the correlation of stereologically estimated volume-weighted mean nuclear volumes (MNV) with Gleason score in prostate adenocarcinomas. To estimate the MNV the point sample intercepts method was used. MNV was significantly associated with tumour differentiation, suggesting that estimates of MNV are prognostically equal or superior to morphological gradin...

We analyse an argument of Deutsch, which purports to show that the deterministic part of classical quantum theory together with deterministic axioms of classical decision theory, together imply that a rational decision maker behaves as if the probabilistic part of quantum theory (Born’s law) is true. We uncover two missing assumptions in the argument, and show that the argument also works for a...