نتایج جستجو برای: gliclazide
تعداد نتایج: 499 فیلتر نتایج به سال:
Abstract Background The current study was carried out to evaluate the possible application of Musa balbisiana starch in formulation mucoadhesive microsphere for oral delivery gliclazide (GLZ). objective improve bioavailability along with prolongation its duration action a better glycaemic control. Ionic gelation technique employed formulating dosage form. Optimization batches by response surfac...
OBJECTIVE To determine the association between use of sulphonylureas and risk of hypoglycaemia in relation to renal function and sulphonylurea metabolic group compared with use of metformin. DESIGN Population based cohort study using routinely collected data from general practices in England. SETTING Clinical Practice Research Datalink (CPRD) database, 2004-12. PARTICIPANTS 120 803 ne...
Glizid-M is the fixed dose combination of Gliclazide (80mg) and Metformin (500mg) indicated for the treatment of non-insulin dependent diabetes mellitus; type 2 diabetes with or without obesity in adults. The present post marketing surveillan ce evaluated the efficacy, safety and tolerability of Glizid-M in 497 patients with type 2 diabetes. It was an open labelled, non-comparative, multi centr...
Several lines of evidence suggest that ATP-sensitive potassium (KATP) channels are involved in glucose uptake by insulin target tissues. The aim of the present study was to prove directly the effect of KATP channel activity on glucose transport into cultured human skeletal muscle cells. We used potassium channel openers PCO400 and nicorandil alone or in combination with channel blockers glibenc...
BACKGROUND Previous studies have shown that many within-class differences exist between sulfonylureas (SUs), however, whether differences exist regarding the time it takes between initiating an SU and the need to intensify treatment with insulin is unclear. The aim of this study was investigate the relationships between the three frequently used sulphonylureas, prescribed as dual therapy next t...
AIMS/INTRODUCTION The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel is a key component of insulin secretion in pancreatic β-cells. Activating mutations in ABCC8 encoding for the sulfonylurea receptor subunit of the KATP channel have been associated with the development of neonatal diabetes mellitus (NDM). The aim was to investigate clinical and functional characterization of t...
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