The value of standard γ-globulin with a low titer of antibody to hepatitis B surface antigen (anti-HB(s)) vs hepatitis B immune globulin (HBIG) in prevention of icteric hepatitis B in the military is unclear. Although recent studies have shown a decrease in icteric hepatitis after administration of both types of γ-globulin in populations where acquisition of hepatitis B virus (HBV) is most like...

In 1906, Lewis (1) suggested the possibility that an abnormality in globulin metabolism might play a role in the pathogenesis of amyloidosis because he observed that hyperglobulinemia regularly occurred in horses that developed amyloid as a result of tetanus toxin administration. A similar association between prolonged hyperglobulinemia and the ultimate development of amyloidosis has been noted...

We conducted a community-based cross-sectional study to evaluate the role of genetics in determining the individual difference in total testosterone and sex hormone-binding globulin levels. Study participants comprised 730 Korean men consisting of 142 pairs of monozygotic twins, 191 pairs of siblings, and 259 father-offspring pairs from 270 families who participated in the Healthy Twin study. S...

Serum is generally considered to contain at least two proteins, albumin and globulin, differing both in their isoelectric points, (literature summarized by Freundlich) and molecular weights (Svedberg and Sj6gren), and readily separable by half-saturation with ammonium sulfate, which precipitates the globulin. There has been considerable investigation tending to show that the globulin fraction i...

In the chicken, serum gamma globulin (CGG) is preferentially transferred by the follicular epithelium of the ovary to the developing ova. The concentration of gamma globulin in the yolk of the unfertilized egg is many times the concentration of chicken serum albumin (CSA). This transfer occurs largely during the 4 to 5 days preceding ovulation when the growth of the ovum is most rapid. Thus, in...

1. Incorporation of S(35)-labeled amino acids into serum proteins has been studied in neonatal and developing rabbits. It was found that, per unit weight, neonatal rabbits synthesized only about 1/36 of the gamma globulin, 1/7 of the beta globulin, (1/2) of the alpha globulin, and (1/8) of the albumin that an adult synthesized. The growing rabbit developed the ability to synthesize various seru...

The cleavage into large fragments of both normal and immune rabbit y-globulin by cysteine-activated papain was reported by Porter (1, 2). In the case of immune y-globulin the antibody activity was found associated with two of the three principal fragments isolated. Nisonoff et al. (3) have carried out the cleavage of rabbit immune y-globulin into similar fragments with a sedimentation constant ...

Human urine contains proteins that have been demonstrated to be antigenically identical with serum immunoglobulins (1-8). The immunoglobulins usually present in urine have been 7 S -y-globulin and 382A-globulin (3,7), whereas /82M-globulin has been found in only a few cases (9). A low molecular weight protein, antigenically related to 7 S y-globulin, has also been observed (2, 4-8). This low mo...

An immunohistologic complement fixation test has been used in an effort to detect immune complexes in sections of kidney from rats injected with rabbit anti-rat kidney serum and in sections of biopsied kidneys from four humans with membranous glomerulonephritis. Sections of the rat and human kidneys were treated with fluorescein-conjugated anti-rabbit globulin or antihuman globulin respectively...

Rheumatoid factors in the sera of patients with rheumatoid arthritis appear to be specifically directed against genetically determined "antigens" in human gamma-globulin. At least eight rheumatoid factors of differing specificity exist; usually several are present in combination in the same serum. The different rheumatoid factors can be readily detected through their pattern of reactivity with ...