We have performed in parallel, in 19 children with acute lymphoblastic leukemia, a quantitative determination of glucocorticoid levels, in vitro steroid induced inhibition of nucleic acid precursors, and a short-term clinical trial of corticosteroids alone, before the treatment was given, which included corticosteroids and other drugs. From our results it appears that high glucocorticoid recept...

In humans, the syndrome of cori ¡solresistance is characterized by the absence of signs and symptoms of Cushing's syndrome, elevated total and unbound plasma cortisol concentrations, and increases in urinary free cortisol excretion and plasma adrenocorticotropic hormone. In one family, a severely affected member had hypertension and hypokalemic alkalosis associated with increased plasma concen...

one of the main components of the stress system is hypothalamus- pituitary-adrenal (hpa) axis. acute activation of µ-opioid receptors increases the activity of the hpa axis, leading to release of acth and corticosterone. glucocorticoids can change behaviors, depend on age but there were no evidences about the interaction between age, opioid system and glucocorticoids. in this experiment, effect...

Glucocorticoids and mineralocorticoids regulate diverse functions important to maintain central nervous system, cardiovascular, metabolic, and immune homeostasis. The actions of these hormones are mediated by their specific intracellular receptors: the glucocorticoid (GR) and mineralocorticoid (MR) receptors. Pathologic conditions associated with changes of tissue sensitivity to these hormones ...

Glucocorticoid receptors of rat kidney and liver were compared by physicochemical and immunochemical methods to investigate the role of proteolysis in the formation of corticosteroid binder IB. Kidney cytosol prepared in the presence of sodium molybdate contained receptor forms comparable to rat liver glucocorticoid receptor; [3H]triamcinolone acetonide-labeled receptors eluted from Sephacryl S...

Introduction Glucocorticoids (GC) are mainstay of therapy in asthma but over 50% of asthmatics do not respond to inhaled or oral glucocorticoids. This makes glucocorticoid resistance in asthma a challenging healthcare problem associated with significant morbidity and life-threatening disease progression. Physiologic and pharmacologic actions of glucocorticoids are mediated through binding to th...

The molecular basis for the receptorless (r-) and activation-labile (act1) phenotypes of glucocorticoid-resistant mutants isolated from glucocorticoid-sensitive human leukemic CEM-C7 cells was determined. Clones isolated from a complementary DNA library prepared from r- ICR27TK.3 cells, in which one glucocorticoid receptor (GR) gene has been deleted, contained a single adenosine to thymidine tr...

Inflammation is a body response towards any injury or tissue damage. It involves the accumulation of neutrophils and release inflammatory mediators. ANXA1, 37 kDa glucocorticoid inducible protein plays an important role in resolving inflammation. The unique N-terminal its mimetic peptide exert strong anti-inflammatory actions. This study was conducted to review roles ANXA1 inflammation identify...

A major unanswered question of glucocorticoid and progesterone action is how different whole cell responses arise when both of the cognate receptors can bind to, and activate, the same hormone response elements (HREs). We have previously documented that the EC50 of agonist complexes, and the partial agonist activity of antagonist complexes, of both glucocorticoid receptors (GRs) and progesteron...