To identify distinct biological pathways of glucose metabolism, we conducted a systematic evaluation of biochemical changes after an oral glucose tolerance test (OGTT) in a community-based population. Metabolic profiling was performed on 377 nondiabetic Framingham Offspring cohort participants (mean age 57 years, 42% women, BMI 30 kg/m(2)) before and after OGTT. Changes in metabolite levels wer...

Fasting is only necessary prior to the oral sugar (Karo® syrup) test and other dynamic oral glucose challenge tests. This entails leaving 1 flake of hay in the stall or dirt pen after 10:00 p.m. the night prior to testing. Fasting is not necessary prior to measurement of resting insulin and glucose concentrations. If measured in the fed state, a resting insulin concentration > 360 pmol/L (50 μU...

OBJECTIVE The purpose of this study was to test the hypothesis that any degree of abnormal glucose homeostasis detected on antepartum screening for gestational diabetes mellitus (GDM) should be associated with an increased risk of postpartum pre-diabetes or diabetes. RESEARCH DESIGN AND METHODS In this prospective cohort study, 487 women underwent 1) antepartum GDM screening by a glucose chal...

BACKGROUND In healthy individuals, insulin administration causes an increase in forearm blood flow which is dependent on the effects of insulin on the vascular endothelium. Glucose, administered as an intravenous bolus, produces a transient hyperinsulinaemic response. We hypothesized that the insulin response to an intravenous glucose challenge during the intravenous glucose tolerance test migh...

BACKGROUND Insulin resistance is a significant risk factor in the pathogenesis of type 2 diabetes. This article presents pilot study results of the dynamic insulin sensitivity and secretion test (DISST), a high-resolution, low-intensity test to diagnose insulin sensitivity (IS) and characterize pancreatic insulin secretion in response to a (small) glucose challenge. This pilot study examines th...

AIM To compare sonographic measurements of fetal fat tissue in pregnancies complicated by gestational diabetes (GD), with patients undergoing either a diet only or a combined diet and insulin treatment, to those obtained in pregnancies with a normal glucose challenge test. METHODS Forty-five singleton pregnancies complicated by GD but free of any other maternal disease known to affect fetal g...

OBJECTIVE To propose new cutoffs in plasma glucose levels in screening and diagnosis of gestational diabetes mellitus (GDM) in the first trimester of pregnancy. METHODS A 50-gram oral glucose challenge test (GCT) was performed in 1,716 singleton pregnancies at 6-14 weeks' gestation. In those with a positive GCT, a 100-gram glucose tolerance test (GTT) was carried out. The GCT and as necessary...

Aims: To determine effect of nifedipine on blood glucose levels through oral glucose tolerance test in normoglycemic albino Rats and magnitude of its effect on basal v/s glucose induced glycemic value. Methods: Normal adult albino rats of either sex weighing between 150 – 200g were randomly divided into 2 groups(n=6); Control(distilled water-1ml/rat) and Test(nifedipine-1.5mg/kg BW) and the res...