Background: Urtica dioica is known as an anti-hyperglycemic plant. Urtica dioica distillate (UD) is a traditional Iranian drink, locally known as “aragh gazaneh”. In spite of its widespread consumption in Iran, according to traditional Iranian medicine, there is no scientific report on the usefulness of UD for diabetic patients. This survey was designed to evaluate its protective effects for th...

1. Modelling analysis of intravenous glucose tolerance test glucose and insulin concentrations can provide measures of insulin sensitivity and metabolism from a single straightforward procedure. However, little is known of the effects of blood arterialization on model-derived parameters. 2. Intravenous glucose tolerance tests were carried out on 18 subjects, with measurement of glucose and insu...

To determine whether hemodynamic changes can modulate insulin action in vivo, we administered angiotensin II (AII) to normal men under three separate, euglycemic conditions. First, in the presence of physiological hyperinsulinemia (approximately 115 microU/ml), infusion of AII at rates of 2, 10, and 20 ng/min per kg caused significant elevations of blood pressure, whole-body glucose clearance, ...

Aim: This study aimed to assess the effects of different kinds diet, which were similar in total energy density but carbohydrate and fats, on some blood parameters type 2 diabetics. 
 Materials Methods: In this study, 33 diabetics, participants offered two lunches within 7 days intervals. Venous samples collected from half an hour before after consumption these meals (0-180 minutes). Blood...

Repaglinide is an oral blood-glucose-lowering drug used to manage type-2 diabetes mellitus by lowering post-prandial glucose stimulating insulin secretion from pancreatic beta cells. According the biopharmaceutical classification system, repaglinide falls under class II category. For such drugs, limited solubility and poor dissolution rate are major hurdles overcome formulation scientists, as t...

abstract objective: insulin resistance and hyperinsulinemia are common among the women with polycystic ovarian syndrome (pcos). familial aggregation of pcos has implications on the role of heredity in this disease. the aim of this study was to evaluate insulin resistance among the fathers, mothers, and siblings of the women with pcos referring to the clinics affiliated to shiraz university of m...

The study aimed at determining the effect of acid modified porcine mucin powder on the release and permeation of insulin in transdermal patches. Various batches of insulin patches were prepared by solvent casting method using polysorbate 80 as emulsifying agent and acid treated and untreated mucin powders as base. The patches were evaluated for their physical properties, folding endurance, moi...

This paper explores the possibility of using an asymptotic state observer for the real-time reconstruction of insulin blood concentration in an individual by using only measurements of the glucose blood concentration. The interest in this topic relies on the fact that the glucose measurements are much more economical and faster then the insulin measurements. An algorithm providing reliable insu...

Pancreatic β-cells dysfunction and impairment of insulin action usually leads to hyperglycemia. Punica granatum L. is a well-known traditional herbal remedy in Iran due to its positive effects on ameliorating blood glucose homeostasis. In this study, we aimed to investigate and compare the pomegranate fruits aqueous extract (PE) on glucose and lipid metabolisms in normal and Alloxan-induced dia...