Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania (Leishmania) mexicana, the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the glibenclamide-resistant strain.

the purpose of this study was to determine the adherence to oral hypoglycemic medications and associated factors in type 2 diabetes mellitus patients who were referred to the isfahan endocrinology and metabolism research centre (iemrc). convenience sampling was used to enroll 248 patients with type 2 diabetes in a prospective study at iemrc from january 2007 to january 2008. patients had to be ...

Glyburide (GLB) is an oral sulfonylurea, commonly used for the treatment of gestational diabetes mellitus. It has been reported that the clearance of GLB in pregnant women is significantly higher than that in nonpregnant women. The molecular mechanism by which pregnancy increases the clearance of GLB is not known, but it may be caused by increased CYP3A activity. Because liver tissue from pregn...

Exposure to untreated gestational diabetes mellitus (GDM) in utero increases the risk of obesity and type 2 adulthood, increased adiposity GDM-exposed infants is suggested as a plausible mediator this later-life metabolic disorders. Evidence equivocal regarding impact good glycaemic control GDM mothers on infant at birth. We systematically reviewed studies reporting fat mass (FM), percent (%FM)...

Sulfonylureas, widely used as hypoglycemic agents in adults with type 2 diabetes, have neuroprotective effects preclinical models of central nervous system injury, and children neuropsychomotor impairments linked to neonatal diabetes secondary ATP-sensitive potassium channel mutations. In the human rodent retina, we show that glibenclamide-activated sulfonylurea receptor 1 (SUR1) is expressed r...