The effects of the commonly employed systemic vasodilators phentolamine, nitroprusside, and intravenous glyceryl trinitrate on cardiac performance, peripheral resistance, and vascular capacitance, as judged by changes in left ventricular filling pressure, were compared in 29 patients studied within 24 hours after the onset of acute myocardial infarction. To provide a common basis for comparison...

In order to investigate interrelations between early diastolic events, simultaneous apex-, phono-,f and echocardiograms were recorded in 10 normal and 55 patients with ischaemic heart disease. In normal subjects isovolumic relaxation time measured as A2 to mitral valve opening was 72 +/- 9 ms, the interval A2-0 point was 116 +/0 15 ms, and the amplitude of the f wave of the apexcardiogram relat...

Atherosclerosis is a lifelong process involving artery wall thickening. Increased wall thickness has been widely adopted as a preclinical surrogate marker of atherosclerosis. A prerequisite for such a surrogate marker is that it is a structural characteristic of the vessel wall that is not subject to acute changes. The purpose of this study was to examine the acute effects of vasodilator drug a...

The major lipids ofthedogfish (Squalusacanthias) are the diacyl glyceryl ethers and triglycerides. These classes of compounds in the flesh (dorsal section) and liver were separated by thin-layer chromatography. The glyceryl ethers and/or fatty acids resulting from saponification of each of these fractions were analyzed by gas-liquid chromatography as their isopropylidene and methyl ester deriva...

I . Tridodecyl glyceryl ether (I ,z,3-tridodecoxypropane) was prepared and purified for use as a lipid-soluble indicator of fat absorption. It was separated from other lipids present in samples of diet, digesta and faeces by thin-layer chromatography and determined by gasliquid chromatography. 2. In balance studies using rats which received a semi-purified diet containing beef tallow, 97-98 "/o...

In a study designed to investigate potential non-parenteral treatment for chronic heart failure, hydrallazine, 225 to 300 mg per day, was given orally to 9 patients. There was no significant change in heart rate or mean arterial pressure as cardiac output increased. Left ventricular stroke work increased significantly and pulmonary artery wedge pressure fell. Systemic and pulmonary vascular res...