Antineoplastic agents may be very effective in the first round of combination chemotherapy; however, upon subsequent treatment, many tumours display resistance. In many instances , drug resistance is observed to multiple agents which differ in structure as well as in their mechanism of action. Development of such multidrug resistance (MDR) is a major obstacle in the treatment of a variety of ma...

The elaboration of enamel matrix glycoprotein was investigated in secretory ameloblasts of incisor teeth in 30-40-g rats. To this end, the distribution of glycoprotein was examined histochemically by the use of phosphotungstic acid at low pH, while the formation of glycoprotein was traced radioautographically in animals sacrificed 2.5-30 min after galactose-(3)H injection. Histochemically, the ...

glanzmann's thrombasthenia (gt) is a rare, genetically inherited platelet disorder in which the platelet glycoprotein iib/iiia (gp iib/iiia) complex is either deficient or, dysfunctional. the incidence is about 1 in 1,000,000. this case report deals with a 4 year-old girl diagnosed with gt presenting with dental caries and periapical lesions in the primary mandibular first molars. to provide th...

AIMS (1) To investigate the immunohistochemical expression of the multidrug resistance gene (MDR1) product P-glycoprotein in histological samples from 31 hepatocellular carcinomas (HCCs); and (2) to correlate the results with cell proliferation, p53 expression, the disease-free interval, and cumulative patient survival. METHODS C219 (a monoclonal antibody), CM-1 (a polyclonal rabbit anti-huma...

Objective: Coronaviruses and paramyxoviruses, both of which are RNA viruses, have similar structural glycoprotein characteristics. It is considered that antibodies developed against these structures may protect by cross-reaction because the glycoproteins viruses related to their ability infect cell.