Crucial events in myogenesis rely on the highly regulated spatiotemporal distribution of cell surface heparan sulfate proteoglycans to which are associated growth factors, thus creating a specific microenvironment around muscle cells. Most growth factors involved in control of myoblast growth and differentiation are stored in the extracellular matrix through interaction with specific sequences ...

Changes in the concentration of the major glycosaminoglycan compounds were measured during healing of severed Achilles tendons in rabbits. Using zone electrophoresis for separation, and densitometry for quantitation of these compounds, their concentrations could be measured in each of several portions of the tendon and its associated muscle. Immediately after injury, the concentration of hyalur...

The potential of using capillary electromigration techniques for biomimicking essential biological interactions is described. most commonly used methodologies with their exploitation in calculations kinetics and biomolecular interaction data are briefly discussed. Experimental approaches bimolecular some selected examples, including lipoproteins, glycosaminoglycan, liposomes DNA or RNA interact...

Nanoparticle-Drug Conjugates To combat pancreatic cancer with a dismal prognosis, self-assembled nanoparticle-drug conjugate is synthesized in article 2203011 by Peng Huang, Shijun Wen, Jiang Yang, and co-workers. Based on chemically-modified sulfated glycosaminoglycan derivatives, (NDC) efficiently encapsulates cyclodiaryliodonium NOX inhibitor from pooled screening, enabling hyaluronidase-act...