New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated. Different responses among species of Leishmania make species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis was evaluated in go...

In constant dim illumination the hamster estrous cycle free-runs with a period that is a quadruple multiple of the concurrently recorded rhythm of wheel-running activity; both activity and estrous cycles are generated by biological clocks. Maintenance of stable phase angle differences between heat onset and running onset before and after treatment with deuterium oxide suggests that a common cir...

The carcinogens 9,10-dime thy 1-1,2-benzanthracene, 20-methylcholanthrene, 3,4benzpyrene, 1,2,5,6-dibenzanthracene, 1,2-benzanthracene, and 2-anthramine have been tested topically in the Syrian golden hamster. The mouse skin tumor-promoting agents, croton oil and polyoxyethylene sorbitan monostearate (Tween 60), have been tested on hamster skin following a single applica tion of 9,10-dimethyl-l...

Dimethyl sulphoxide (DMSO) is a relatively simple organic compound with a molecular weight of 78. It has been reported to be exceptionally non-toxic and has been used extensively in biological systems as a cell preservative, including freeze storage (Porterfield & Ashwood-Smith, 1962; Dougherty, 1962), and as a radioprotective agent against X-irradiation in mice (Ashwood-Smith, 1961). Recent cl...

Values for hemoglobin, erythrocytes, volume of packed cells, leucocytes, and their distribution, and red blood cell diameter are presented as determined on a group of 114 hamsters of both sexes and of various ages.

Ebola hemorrhagic fever (EHF) is a severe viral infection for which no effective treatment or vaccine is currently available. While the nonhuman primate (NHP) model is used for final evaluation of experimental vaccines and therapeutic efficacy, rodent models have been widely used in ebolavirus research because of their convenience. However, the validity of rodent models has been questioned give...

In vitro screening using the cell-free prion protein conversion system indicated that certain rodents may be susceptible to chronic wasting disease (CWD). Therefore, CWD isolates from mule deer, white-tailed deer, and elk were inoculated intracerebrally into various rodent species to assess the rodents' susceptibility and to develop new rodent models of CWD. The species inoculated were Syrian g...

VERSTER, ANNA. Preliminary report on the golden hamster as a definitive host of Taenia so!ium Linnaeus, 1758 and Taenia saginata Goeze, 1782. Onderstepoortj. vet. Res. 38 (1) 63-64 (1971). Injections of an immunosuppressant drug, methyl prednisolone acetate, increase the susceptibility of golden hamsters to the adult stage of Taenia solium Linnaeus, 1758. At dosage rates of 10, 5, 2 and 1 mg pe...

7,12-Dimethylbenz(a)anthnacene (DMBA) and its 1-, 2-, 5-, and 11-fluono derivatives were tested to determine their mutagenicity for ouabain resistance in Chinese hamster V79 cells and their tumor-initiating activity in mouse skin. Inasmuch as V79 cells do not metabolize polycyclic aro matic hydrocarbons, mutagenesis was tested both in the presence and in the absence of golden hamster embryo cel...

7,12-Dimethylbenz(a)anthnacene (DMBA) and its 1-, 2-, 5-, and 11-fluono derivatives were tested to determine their mutagenicity for ouabain resistance in Chinese hamster V79 cells and their tumor-initiating activity in mouse skin. Inasmuch as V79 cells do not metabolize polycyclic aro matic hydrocarbons, mutagenesis was tested both in the presence and in the absence of golden hamster embryo cel...