BACKGROUND AND OBJECTIVE Transient activation of the hypothalamic-pituitary-gonadal axis with a sex steroid surge is observed in boys and girls during the first months of life. However, the role of sex steroids in the regulation of growth has not been substantiated in infancy. We tested the hypothesis that testosterone (T) surge, known to be higher in infant boys than in girls during the transi...

Normal puberty is associated with the onset and progressive activation of the hypothalamic-pituitary-gonadal (HPG) axis and the resultant development of secondary sexual characteristics. Puberty begins with increasing nocturnal pulsatile hypothalamic GnRH secretion, which gradually occurs throughout the 24-h day. Pulsatile GnRH stimulates pituitary FSH and LH secretion, ultimately stimulating g...

F. Hadziselimovic, MD, University Children’s Hospital Basel, Römergasse 8, CH-4005 Basel (Switzerland) Cryptorchidism is a disorder of the hypothalamic-pituitary-gonadal axis and is not a malformation. We advocate early treatment (10 months of age) to avoid pronounced secondary gonadal changes starting after 12 months of age. The lower the testes are situated the better their histology; the you...

Background: Our aim was to evaluate the recovery rate of ovarian function and the activity of hypothalamus-hypophiseal- gonadal axis following transplantation of vitrified ovaries. Materials and Methods: Five weeks-old female Wistar Rats were distributed randomly in two experimental groups; Fresh Transplanted, Vitrified-Transplanted and 8 weeks-old female Wistar rats were considered as control ...

Background Pyrethroids are commonly used as insecticides for both household and agricultural applications, and have recently been linked to endocrine disruption. Cypermethrin is a type П pyrethroid which is used widely throughout the world. The present study was aimed to investigate the effects of cypermethrin on the sexual behaviour and plasma level of pituitary-gonadal hormones of adult male ...