Many researchers have discussed fecundity on a per patient or per ovarian follicle basis. In contrast, this study was undertaken on a per ovary basis, and tests the hypothesis that there is a relationship between the fecundity of the bilateral ovaries in an individual patient and the incidence of apoptotic granulosa cells. The two ovaries of 10 women undergoing ovulation induction for in-vitro ...

This case report describes the first attempt to treat imminent ovarian hyperstimulation syndrome (OHSS) by using a gonadotrophin-releasing hormone (GnRH) antagonist. A 33 year old, normo-ovulatory woman undergoing in-vitro fertilization received daily subcutaneous injections of 150 IU of recombinant follicle-stimulating hormone (recFSH) from cycle day 2, together with GnRH antagonist (ganirelix...

Rudd, B. T., Rayner, P. H. W., Smith, M. R., Holder, G., Jivani, S. K. M., and Theodoridis, C. G. (1973). Archives of Disease in Childhood, 48, 590. Effect of human chorionic gonadotrophin on plasma and urine testosterone in boys with delayed puberty. The plasma testosterone and/or urine testosterone levels after 1500 units of human chorionic gonadotrophin (HCG) for four days have been measured...

A highly purified and potent gonadotrophin in pregnant mare serum has been prepared. The preparation has been shown to be electrophoretically homogeneous in the Tiselius apparatus. The mobilities of the substance have been determined over a wide range of hydrogen ion concentrations. The isoelectric point lies at pH 2.60-2.65 and the value of See PDF for Equation is 4.0 x 10(-5). Some chemical c...

p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells. More than 50% of human tumors contain mutation or deletion of p53. Gonadotrophin-releasing hormone (GnRH), as the ligand of Gonadotrophin-releasing hormone receptor (GnRH-R), was used to deliver p53 into tumor cells. The p...

The treatment of infertility in polycystic ovary syndrome (PCOS) associates lifestyle measures, and the use of drugs to induce ovulation. In this endeavour, clomifene citrate (CC) should be used as the first line of treatment, followed eventually by low dose gonadotrophin stimulation, as a second line. In rare cases, in case of failure of the CC treatment, ovarian drilling i.e. laparoscopic ova...

Ovarian hyperstimulation syndrome (OHSS) remains a major complication of IVF. Triggering ovulation with human chorionic gonadotrophin (HCG) (as a surrogate to LH) is a major factor in the initiation of OHSS. The pathological process usually intensifies if pregnancy is achieved, as the rising endogenous HCG overstimulates the corpora lutea. Decreasing HCG trigger dose does not prevent OHSS. Gona...

This study examined the effects of human menopausal gonadotrophin (HMG) or human chorionic gonadotrophin (HCG) priming on cumulus-oocyte complex (COC) morphology, oocyte maturation and embryo development in patients undergoing in-vitro maturation (IVM) cycles. The patients were primed with nothing (group 1), low-dose HMG (group 2) or 10,000 IU HCG (group 3) before oocyte retrieval. COC with dis...

False negative reactions in pregnancy testing with frogs and toads can be avoided by concentrating the urinary chorionic gonadotrophin. If unconcentrated urines are used, the incidence of these reactions may be as high as 43.7 per cent' and 50 per cent.8 Inaccuracy occurs most frequently during the late summer and early autumn months when many batrachians are relatively insensitive, and also wh...

in this study, we aimed to investigate reproductive performance in estrus-induced zandi ewes treated with equine chorionic gonadotrophin (ecg) injection in combination with prostaglandin f2α (pgf2α)and gonadotrophin releasing hormone (gnrh) during non-breeding season. the estrous cycle was synchronized using controlled internal drug release (cidr) for 12 days. the ewes were randomly assigned to...