BACKGROUND AND PURPOSE Spectroscopic examination of multiple sclerosis (MS) patients has revealed abnormally low N-acetyl-aspartate (NAA) signal intensity, even in brain tissue that appears normal on high-resolution structural MR images but has yielded inconclusive evidence to distinguish the well-documented clinical differences between MS subtypes. This study used proton MR spectroscopic imagi...

Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine, SNUMRC, Clinical Research Institute, Seoul National University Hospital Department of Radiology, CHA Hospital, Pochon CHA University College of Medicine Received February 4, 2006 ; Accepted July 31, 2006 Address reprint requests to : In-One Kim, M.D., Department of Radiology, Seoul Na...

BACKGROUND Combat-related PTSD has been associated with reduced gray matter volume in regions of the prefrontal and temporal cortex, hippocampus, insula, and amygdala. However, the relationship between gray matter volume and specific deployment and post-deployment experiences has not been investigated. The aim of this study was to delineate how such experiences may contribute to structural brai...

Chronic pain can be understood not only as an altered functional state, but also as a consequence of neuronal plasticity. Here we use in vivo structural MRI to compare global, local, and architectural changes in gray matter properties in patients suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA), relative to healthy controls. We find that...

BACKGROUND The authors sought to map gray matter changes in Attention Deficit Hyperactivity Disorder (ADHD) using a novel technique incorporating neuro-imaging and genetic meta-analysis methods. METHODS A systematic search was conducted for voxel-based structural magnetic resonance imaging studies of patients with ADHD (or with related disorders) in relation to comparison groups. The authors ...

Previous work suggests that spatial expertise in licensed London taxi drivers is associated with differences in hippocampal gray matter volume relative to IQ-matched control subjects. Here we examined whether non-spatial expertise is associated with similar hippocampal gray matter effects. We compared medical doctors who, like taxi drivers, acquire a vast amount of knowledge over many years, wi...