Polyethylenimine (PEI) is a well-known cationic polymer which has high transfection efficiency due to its buffering effect. However, nondegradability, cytotoxicity, aggregation, and short-circulation time in vivo still need to be overcome for a successful gene delivery. Degradable, hyperbranched poly(ester amine)s (PEAs) based on poloxamer diacrylate and low molecular weight branched PEI, were ...

Plant diseases are caused by pathogen populations continuously subjected to evolutionary forces (genetic flow, selection, and recombination). Ascochyta blight, caused by Mycosphaerella pinodes, is one of the most damaging necrotrophic pathogens of field peas worldwide. In France, both winter and spring peas are cultivated. Although these crops overlap by about 4 months (March to June), primary ...

The biochemical composition of the new fish culinary product is considered. results make it possible to attribute functional products. Compositions with a given set nutritional value indicators were simulated by optimizing multicomponent formulations. Products are characterized preset properties: functionality, balance amino acid, mineral and vitamin compositions, high organoleptic characterist...

BACKGROUND Despite the development of advanced drug testing systems, both deliberate and inadvertent doping in sports is increasing in elite, amateur and school sports. As a result, alternative approaches that seek to influence an athlete's attitudes are needed to address the growing doping concerns that threaten both the health and well being of the athlete as well as the legitimacy of the spo...

In January, Harold Varmus will begin the next stage in an unusual career. He’s gone from English literature to medicine to bench science to Washington science bureaucrat, and now he becomes the well-paid (some would say extremely well-paid) president of a private, not-for-profit treatment and research facility, the Memorial Sloan Kettering Cancer Center in New York. He’s succeeded in everything...

We have evaluated the effects of an elimination diet in 5 patients with hypersensitivity vasculitis and a personal or family history of allergy. The presence of autoimmune disorders, infections and neoplastic diseases was excluded on the basis of physical examination, clinical history and laboratory data. Three patients had elevated serum immune complexes and evidence of complement consumption ...

Edamame, also called mao dou in China, is a large-seeded (seed dry wt. >250 mg/seed) green vegetable soybean [Glycine max (L.) Merr., Fabaceae] cooked and served in pods as snack-like peanuts (Arachis hypogaea) (Shurtleff 2001). In Asia, where edamame is an important vegetable (Fig. 1), farmers harvest stems with fresh green pods before full maturity when pods are fully filled, nearly 80% matur...

We present a detailed analysis of the rest-frame optical emission line ratios for three spectroscopically confirmed galaxies at $z>7.5$. The were identified in James Webb Space Telescope (JWST) Early Release Observations field SMACS J0723.3$-$7327. By quantitatively comparing Balmer and oxygen these with various low-redshift "analogue" populations (e.g. Green Peas, Blueberries, etc.), we show t...