The support vector machine (SVM) is the state-of-the-art classification method, and the doubly regularized SVM (DrSVM) is its important extension based on the elastic net penalty. DrSVM has been successfully applied in handling variable selection and while retaining (or discarding) correlated variables. However, it is challenging to solve this model. In this paper we develop an iterative l2-SVM...

Skeletal and cardiac muscles are remarkable biological machines that support and move our bodies and power the rhythmic work of our lungs and hearts. As well as producing active contractile force, muscles are also passively elastic, which is essential to their performance. The origins of both active contractile and passive elastic forces can be traced to the individual proteins that make up the...

The radicular lingual grooves act as a nidus for plaque accumulation which destroys the sulcular epithelium and the periodontium, resulting in the formation of a localized periodontal lesion. If inflammation spreads to the pulp through defects in the groove, a primary periodontic/secondary endodontic lesion develops.Successful treatment of the groove depends on the ability to eradicate inflamma...

I calculate the quantum states for He atom in the potential of an external groove of the single wall carbon nanotube bundle. The calculated ground state energy is found to be in fair agreement with the experimental estimate which suggests that the outer groove site is a preferential site for the adsorption of He gas in the samples studied experimentally. I also calculate the specific heat of lo...

cis-Diamminedichloroplatinum(II), generally referred to as cisplatin (see figure), is widely used as a chemotherapeutic agent to cure solid tumor cancers, such as testicular and ovarian cancer [1]. The clinical use of cisplatin is beyond any doubt very successful, but the treatment is accompanied by serious side effects and acquired tumor resistance. In order to decrease or to overcome these pr...

BACKGROUND Apart from transepicondylar axis, the native femoral sulcus was also reported to be used as a guide for the femoral component position in total knee arthroplasty (TKA). However, it was not shown in patients with severe knee osteoarthritis. This study was conducted to compare the position of trochlear groove in patients with and without osteoarthritis, and to assess whether trochlear ...

Adsorption of monovalent and multivalent cat-and anions on a deoxyribose nucleic acid (DNA) molecule from a salt solution is investigated by computer simulation. The ions are modelled as charged hard spheres, the DNA molecule as a point charge pattern following the double-helical phosphate strands. The geometrical shape of the DNA molecules is modelled on different levels ranging from a simple ...

CD1e is the only human CD1 protein existing in soluble form in the late endosomes of dendritic cells, where it facilitates the processing of glycolipid antigens that are ultimately recognized by CD1b-restricted T cells. The precise function of CD1e remains undefined, thus impeding efforts to predict the participation of this protein in the presentation of other antigens. To gain insight into it...

Recurrent patellar instability can result from osseous abnormalities, such as patella alta, a distance of >20 mm between the tibial tubercle and the trochlear groove, and trochlear dysplasia, or it can result from soft-tissue abnormalities, such as a torn medial patellofemoral ligament or a weakened vastus medialis obliquus. Nonoperative treatment includes physical therapy, focusing on strength...