The aim of the present study was to investigate the expression of B7-H1 and B7-H4 in ovarian neoplasm tissues and to examine their clinical relevance. A total of 112 ovarian biopsies were collected from patients with epithelial ovarian cancer (EOC) and 10 were taken from ovarian benign neoplasms. The samples were processed in paraffin tissue chips, and subjected to immunohistochemical staining ...

several of the histone fold helices in free H3.3/H4 complexes. In sum, we have found that DAXX stabilizes a pre-nucleosomal folded form of H3.3/H4 that differs from its final nucleosome form or its form free in solution. While the steps in the folding pathway we studied are certainly tied to the mechanism of chromatin assembly, so to is the massive destabilization we predict occurs to DAXX [HBD...

The H4 technique facilitates text entry with key sequences created using Huffman coding. This study evaluates the use of touch and motion-sensing gestures for H4 input. Touch input yielded better entry speeds (6.6 wpm, versus 5.3 wpm with motion-sensing) and more favourable participant feedback. Accuracy metrics did not differ significantly between the two conditions. Changes to the H4 techniqu...

Protein N(α)-terminal acetylation (Nt-acetylation) is considered one of the most common protein modification in eukaryotes, and 80-90% of all soluble human proteins are modified in this way, with functional implications ranging from altered protein function and stability to translocation potency amongst others. Nt-acetylation is catalyzed by N-terminal acetyltransferases (NATs), and in yeast fi...

To the Editor: Beginning in early May 2011, an outbreak caused by Shiga toxin–producing Escherichia coli O104:H4 was reported in Germany and other countries in Europe. In this outbreak, the number of hemolytic uremic syndrome (HUS) cases has been unusually high (1). As of June 9, 2011, a total of 722 cases of HUS, 19 deaths, and 2,745 cases of enterohemorrhagic E. coli (EHEC) infection were rep...

We tested the hypothesis that biotinylation of K12 in histone H4 plays a role in the cellular response to double-strand breaks (DSB) of DNA in human cells. DSB were caused by treating choriocarcinoma JAr cells with etoposide. Biotinylation of K12 in histone H4 decreased by 50% as early as 10–20 min after initiation of treatment with etoposide. Biotinylation returned to initial levels 30–40 min ...

This study is to investigate the influence of bundling type on ambivalent response which a state having simultaneous conflicting reactions, beliefs, or feelings towards bundled packaging. It hypothesized that hedonic packaging would trigger more than utilitarian one. And it examines moderating roles product characteristic variables such as criteria evaluation attribute and choice set size relat...

This paper introduces extensions H4,p and X8,p of Horn’s double hypergeometric function H4 Exton’s triple X8, taking into account recent Euler’s beta function, confluent function. Among the numerous extended functions, primary rationale for choosing X8 is their comparable extension type. Next, we present various integral representations Euler Laplace types, Mellin inverse transforms, Laguerre p...