Recurrent miscarriages are one or more pregnancy losses before 20-24 weeks of gestation or below a fetal weight of 500 g (Pic. 1). About 1% of women in reproductive age are affected by recurrent miscarriages. The majority of patients are counseled to try to conceive again, and chances are about 60% that the next pregnancy is successful without treatment. However, each additional loss worsens th...

Recurrent miscarriage affect on the female reproductive health and family harmony. For a long time, the medical assessment of the recurrent miscarriage mainly focus on the female. The role of the male factors during the process of recurrent miscarriage has not been known and need further discussing. The male factors involved in the occurrence of adverse pregnancy outcomes may include: chromosom...

In Switzerland preimplantation genetic diagnosis is limited by law to polar body biopsy (PBB). The indications for PBB include unexplained recurrent miscarriage and improvement of the outcome of in vitro fertilisation (IVF) cycles in women at an advanced reproductive age. In this article we report the first birth of a healthy child after polar body biopsy in Switzerland in a case of unexplained...

Annexin A5 is a placental anti-coagulant protein that contains four nucleotide substitutions (M2 haplotype) in its promoter. Studies have shown that this haplotype is a risk factor for recurrent miscarriage (RM). Our aim was to investigate the influence of the M2 haplotype in the gestational timing of miscarriages, assessing the paternal risk and investigate for relationships with known risk fa...

Couples with recurrent miscarriage (RM) and men with poor semen quality may undergo genetic testing as part of the diagnostic work-up. This study explored their knowledge and perception of genetic testing, evaluated psychological wellbeing and identified associated variables. A prospective questionnaire study was conducted in seven clinical genetics centres and referring gynaecological departme...

PROBLEM Published randomized trials of the use of intravenous immunoglobulins (IVIG) as a treatment for recurrent spontaneous abortion (RSA) have produced conflicting results. The purpose of this study was to conduct a systematic review of the current evidence to evaluate the effectiveness of IVIG for RSA. METHOD OF STUDY After a thorough search of the literature, four randomized, double-blin...

BACKGROUND The aim of this review is to discuss the role of aspirin for various conditions in women. METHODS A nonsystematic review of articles published on PubMed(®) that examines the role of aspirin in women. RESULTS Aspirin is associated with a significant reduction of stroke risk in women, which may be linked to age. However, despite this evidence, underutilization of aspirin in eligibl...

Objective: Recurrent pregnancy loss is a global issue. This study was planned in order to evaluate the effects of high dose intravenous immunoglobulin (IV Ig) in primary and secondary unexplained miscarriages in patients of recurrent pregnancy loss. Patients and Methods: Total 168 couples having history of primary or secondary recurrent pregnancy loss were included in the study. They were divid...

Previously, siblings of patients with idiopathic recurrent miscarriage (IRM) have been shown to have a higher risk of miscarriage. This study comprises two parts: (i) an epidemiological part, in which we introduce data on the frequency of miscarriage among 268 siblings of 244 patients with IRM and (ii) a genetic part presenting data from a genome-wide linkage study of 38 affected sibling pairs ...

OBJECTIVE A Cross Sectional population based serological studies was conducted to determine the prevalence and associated risk factors for syphilis women with recurrent miscarriages. METHODS Patient's 5ml whole blood was collected through venepuncture technique. Data were collected by all women answered a questionnaire and by investigating blood sample VDRL test and FTA-ABS test. The study wa...