N-UMEROUS observations in the past decade, culminating in the isolation of the crystalline material and the study of its properties by Theorell [1932; 1934, 1, 2, 3, 4] have established the identity of muscle haemoglobin. Attempts to estimate it, however, have for the most part been concerned with it less as a chemical identity than as that haemoglobin which remains behind after perfusing the t...

To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders. We obtained data on demographics and prevalence of gene variants responsible for haemoglobin disorders from online databases, reference resources, and published articles. A global epidemiological database for haem...

INTRODUCTION Our objective was to determine the interrelationships of interleukin (IL)-6 receptor inhibition with haemoglobin, acute-phase reactants and iron metabolism markers (including hepcidin) in patients with rheumatoid arthritis (RA). METHODS Data of patients receiving tocilizumab or placebo in the MEASURE study were analysed. We investigated associations at baseline and during tociliz...

BACKGROUND Little is known about the significance of haemoglobin genotype in dengue fever severity. This study was undertaken to determine the case fatality ratio and the impact of genotype in patients with sickle cell disease and confirmed dengue fever. METHODS This retrospective analysis included 40 patients with confirmed dengue and sickle cell disease, during the study period (2010-2012)....

BACKGROUND Beta-thalassaemia is a congenital disorder caused by point mutations in a haemoglobin beta-globin chain. The heterozygous form produces microcytosis and normal iron levels, however, haemoglobin electrophoresis shows elevated amounts of haemoglobin A2 and eventually foetal haemoglobin F as well. METHODS Between 2005-2011, in three centres in Slovakia, carriers of beta-thalassaemic g...