Chessells, Judith M., and Wigglesworth, J. S. (1971). Archives of Disease in Childhood, 46, 37. Haemostatic failure in babies with rhesus isoimmunization. Platelet counts, fibrinogen levels, thrombotest, thromboplastin generation screening test, thrombin ratio, and titre of circulating fibrin degradation products, were measured in 30 infants with Rh isoimmunization, of whom 5 had a bleeding ten...

OBJECTIVE To assess the effects of acute stress on inflammatory, haemostatic, rheological, and haemodynamic activity in patients with rheumatoid arthritis (RA) in comparison with patients with osteoarthritis (OA). METHODS 21 patients with RA and 10 with OA underwent a brief mental stress task while standing. Inflammatory, haemostatic, rheological, and haemodynamic variables were measured at b...

Aim: Normal pregnancy is associated with haemostatic changes which have been linked to a complex physiological adaptation but these changes return to that of non-pregnant state at about 4 weeks of post-delivery. This study was undertaken to monitor the haemostatic changes during pregnancy and puerperium in North-Western Nigeria. Materials and methods: Ten pregnant women, aged 17-40 years were m...

UNLABELLED Haemodynamically unstability after severe abdominal injuries requires a new therapeutic strategy. European guidelines recommend: reduced time, non-invasive investigations, avoid massive volemic replacement before surgery. The primary aim of Damage Control Resuscitation protocol is to prevent the lethal triad: hypothermia, acidosis and coagulopathy. The treatment includes contemporary...

Haemostatic and isolating materials may cause local reactions as a foreign body. The case presented here of intracranial granulomatous lesion pertains to a patient operated in two stages due to a huge meningioma. During the first operation the tumour was partially removed. Because of persistent intraoperative haemorrhage haemostatic flakes of Oxycel and Spongostan were applied locally. In order...

Great advances have been made in recent years in understanding the haemostatic system and the molecular and cellular basis of thrombus formation. Although directly targeting factor Xa or thrombin (factor IIa) for effective anticoagulation is now well established, evidence has emerged suggesting that factor Xa and thrombin are involved in other physiological and pathophysiological cellular proce...

The pro- and antiatherogenic roles of apolipoproteins B and A-I, respectively, are well-established although the importance of apolipoprotein A-II remains unclear. There is extensive evidence for the involvement of plasma lipoproteins in haemostatic function. However, in-vivo studies of relationships between haemostatic variables and apolipoprotein concentrations are very limited. Plasma fibrin...

Disseminated intravascular coagulation (DIC) is a syndrome characterised by the systemic activation of blood coagulation, which generates intravascular fibrin leading to thrombosis of smalland medium-sized vessels and eventually contributes to organ dysfunction (1). In addition, the consumption of platelets and coagulation factors may predispose patients with DIC to haemorrhagic complications. ...

Introduction: Recurrent Spontaneous Abortion (RSA) is one of the most common complications of pregnancy and is a major healthcare concern for the medical fraternity. Women experiencing recurrent pregnancy loss are a heterogenous population, therefore specific markers are necessary to identify those who will respond to various treatments. During normal healthy pregnancy there are substantial cha...

BACKGROUND Extracorporeal circuit priming and intravascular volume expansion during cardiopulmonary bypass (CPB) may lead to dilutional coagulopathy and excessive diffuse postoperative bleeding. Prothrombin complex concentrate (PCC) containing clotting factors II (FII), VII (FVII), IX (FIX), and X (FX) could be of potential value in correcting dilutional coagulopathy and reducing blood loss. ...