The pattern of hair growth, morphology of the hair shafts, and the hair root state are described in four girls and two boys with prepubertal hypertrichosis. The exact nosology of this form of excessive hair growth is discussed in relation to hirsuties and the possibility of it representing an 'atavistic' trait.

The hair-growth cycle is an example of a cyclic process that is well characterized morphologically but understood incompletely at the molecular level. As an initial step in discovering regulators in hair-follicle morphogenesis and cycling, we used DNA microarrays to profile mRNA expression in mouse back skin from eight representative time points. We developed a statistical algorithm to identify...

HAIR-GROWTH in the rat occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934). In our colony of randomly mated albino rats the first wave begins at about 5 weeks of age and is complete 3 weeks later; the second wave starts at 8|-9 weeks of age and is not complete until a further 12-14 weeks have elapsed. In both these waves dorsal hairs...

EJD n° 4, vol. 11, July-August 2001 Hair loss or hair thinning is a common complaint in clinical dermatology and patients seeking advice for hair loss are not necessarily bald. In established cases of androgenetic alopecia (AGA) characteristic patterns are easily discernible. However, especially in females the clinician is often challenged by patients with initial stages of AGA where hair loss ...

Lipid signaling, particularly phosphoinositide signaling, plays a key role in regulating the extreme polarized membrane growth that drives root hair development in plants. The Arabidopsis AtSFH1 gene encodes a two-domain protein with an amino-terminal Sec14-like phosphatidylinositol transfer protein (PITP) domain linked to a carboxy-terminal nodulin domain. AtSfh1 is critical for promoting the ...

714 P&T® • December 2005 • Vol. 30 No. 12 NEW DRUGS Eflornithine for Excess Facial Hair in Women Barrier Therapeutics has launched eflornithine HCl cream 13.9% (Vaniqua®) in Canada. The company acquired the exclusive right to distribute this product from Shire in June 2005. This is the only topical prescription product approved by Health Canada for slowing the growth of unwanted facial hair in ...

Sir, An important though rare side effect of reconstruction surgery in oral cavity is persistent hair growth in the recipient site due to intact hair follicles.[1] Hair growth in the transplanted site may be due to the dominant nature of the underlying skin.[2] A 40‐year‐old male came to the dermatology outpatient department with a complaint of excessive hair growth in the oral cavity 2 months ...

Hair follicles undergo continuous cycles of growth, involution and rest. This process, referred to as the hair growth cycle, has a periodicity of weeks to months. At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. In our recent study we found that circadian clock genes play a role in...

Corticotropin-releasing factor (CRF) signaling pathways are involved in the stress response, and there is growing evidence supporting hair growth inhibition of murine hair follicle in vivo upon stress exposure. We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing's syndrome and chronic s...

The control of hair growth in the adult mammalian coat is a fascinating topic which has just begun to be explored with molecular genetic tools. Complex hair cycle domains and regenerative hair waves are present in normal adult (> 2 month) mice, but more apparent in mutants with cyclic alopecia phenotypes. Each hair cycle domain consists of initiation site(s), a propagating wave and boundaries. ...