hairy is a Drosophila pair-rule segmentation gene that functions genetically as a repressor. To isolate protein components of Hairy-mediated repression, we used a yeast interaction screen and identified a Hairy-interacting protein, the Drosophila homolog of the human C-terminal-binding protein (CtBP). Human CtBP is a cellular phosphoprotein that interacts with the C-terminus of the adenovirus E...

The brain, spinal cord, and skin are all derived from the embryonic ectoderm; this common derivation leads to a high association between central nervous system dysraphic malformations and abnormalities of the overlying skin. A myelomeningocele is an obvious open malformation, the identification of which is not usually difficult. However, the relationship between congenital spinal cord malformat...

BACKGROUND The authors describe their experience with the retroauricular temporal flap in facial reconstruction. METHODS Twenty-two (20 females, 2 males) patients with composite tissue defect of various areas of the face have been esthetically reconstructed with a modified Washio flap. This flap is a good choice for facial reconstruction, due to its color match, reliability, feasibility, and ...

Hairy cell leukemia is a rare disease comprising about 2% of lymphoid neoplasms.1 This neoplasm can be confused with other hematologic diseases. Therefore, a differential diagnosis must be performed between classic hairy cell leukemia, hairy cell leukemia variant, and splenic marginal zone lymphoma (SMZL).2 According to the World Health Organization (2008), hairy cell leukemia variant was class...

2 Declaration 4 Acknowledgments 5 Abstracts published during the PhD 6 Table on contents 7 List of figures and tables 9 Chapter 1: General Introduction 20 1.1 History of the study of sensation and pain 20 1.2 The study of thermal sensitivity 24 1.3 Afferent spinal pathways of thermal sensation 31 1.4 Cellular and molecular mechanisms underling cold sensitivity 33 1.5 Abnormal cold sensitivity i...

The brain, spinal cord, and skin are all derived from the embryonic ectoderm; this common derivation leads to a high association between central nervous system dysraphic malformations and abnormalities of the overlying skin. A myelomeningocele is an obvious open malformation, the identification of which is not usually difficult. However, the relationship between congenital spinal cord malformat...

Abstract There is an increasing interest in long-term electrocardiography (ECG) monitoring veterinary clinical practice. ECG the most essential physiological signal diagnosing and managing heart diseases both humans animals. Electrodes are main components that affect quality of acquired signal. This study focuses on development silver-coated textile electrodes for testing (particularly dogs). S...

Impulses were recorded from unmyelinated afferents innervating the forearm skin of human subjects using the technique of microneurography. Units responding to innocuous skin deformation were selected. The sample (n = 38) was split into low-threshold units (n = 27) and high-threshold units (n = 11) on the basis of three distinctive features, i.e., thresholds to skin deformation, size of response...

Restoration of the epidermal barrier is a requirement for burn wound closure. A rapid, reliable, and noninvasive measure of the rate of restoration of the epidermal barrier is not readily available. To monitor the reformation of the epidermal barrier, we measured surface electrical capacitance on cultured skin substitutes (human keratinocytes and fibroblasts attached to collagen-glycosaminoglyc...

Microneurographical recordings from 24 slowly adapting (SA) and 16 fast adapting (FA) cutaneous mechanoreceptor afferents were obtained in the human radial nerve. Most of the afferents innervated the hairy skin on the back of the hand. The afferents' receptive fields were subjected to controlled strains in a ramp-and-hold fashion with strain velocities from 1 to 64%.s(-1), i.e., strain velociti...